Cargando…

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease

Antibody therapies for Alzheimer’s Disease (AD) hold promise but have been limited by the inability of these proteins to migrate efficiently across the blood brain barrier (BBB). Central nervous system (CNS) gene transfer by vectors like adeno-associated virus (AAV) overcome this barrier by allowing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elmer, Bradford M., Swanson, Kurt A., Bangari, Dinesh S., Piepenhagen, Peter A., Roberts, Errin, Taksir, Tatyana, Guo, Lei, Obinu, Maria-Carmen, Barneoud, Pascal, Ryan, Susan, Zhang, Bailin, Pradier, Laurent, Yang, Zhi-Yong, Nabel, Gary J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936806/ https://www.ncbi.nlm.nih.gov/pubmed/31887144 http://dx.doi.org/10.1371/journal.pone.0226245

Ejemplares similares

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease
por: Dodge, James C., et al.
Publicado: (2022)

SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy
por: Delay-Goyet, Philippe, et al.
Publicado: (2016)

Development of nonhuman adenoviruses as vaccine vectors
por: Bangari, Dinesh S., et al.
Publicado: (2006)

Validation of memory assessment in the Starmaze task: Data from 14 month-old APPPS1 mice and controls
por: Schmitt, Julien, et al.
Publicado: (2021)

Adenovirus receptors and their implications in gene delivery
por: Sharma, Anurag, et al.
Publicado: (2009)

Comparative Analysis of Acid Sphingomyelinase Distribution in the CNS of Rats and Mice Following Intracerebroventricular Delivery
por: Treleaven, Christopher M., et al.
Publicado: (2011)

Inhibition of TGF‐β Increases Bone Volume and Strength in a Mouse Model of Osteogenesis Imperfecta
por: Greene, Benjamin, et al.
Publicado: (2021)

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation
por: Christensen, Ditte Z., et al.
Publicado: (2014)

An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
por: Bernardo, Marie, et al.
Publicado: (2021)

Evaluation of Cross-Reactive Cell-Mediated Immune Responses among Human, Bovine and Porcine Adenoviruses
por: Sharma, Anurag, et al.
Publicado: (2010)

Alzheimer's disease: Estimating its prevalence rate in a French geographical unit using the National Alzheimer Data Bank and national health insurance information systems
por: Bailly, Laurent, et al.
Publicado: (2019)

Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes
por: Pradier, Léa, et al.
Publicado: (2023)

Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease
por: Malanda, André, et al.
Publicado: (2019)

A multiclade DNA/Ad vaccines for AIDS: the present and next generation
por: Nabel, Gary J
Publicado: (2006)

The development of gene-based vectors for immunization
por: Nabel, Gary J.
Publicado: (2008)

Genetic, cellular and immune approaches to disease therapy: past and future
por: Nabel, Gary J
Publicado: (2004)

CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria
por: Singh, Kuldeep, et al.
Publicado: (2021)

Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer's Disease
por: Liu, Yan, et al.
Publicado: (2019)

Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
por: Shippy, Daniel C., et al.
Publicado: (2022)

Microsoft Power BI dashboards: step by step
por: O'Connor, Errin
Publicado: (2019)

SharePoint 2013 field guide : advice from the consulting trenches unleashed
por: O,Connor, Errin
Publicado: (2014)

Microsoft SharePoint Foundation 2010: inside out
por: O'Connor, Errin
Publicado: (2011)

Windows Sharepoint Services 3.0: Inside Out
por: O' Connor, Errin
Publicado: (2008)

The development of gene-based vectors for immunization
por: Weiner, David B., et al.
Publicado: (2013)

Development of Gene-Based Vectors for Immunization
por: Weiner, David B., et al.
Publicado: (2018)

Disease-modifying drugs in Alzheimer’s disease
por: Ghezzi, Laura, et al.
Publicado: (2013)

Modifiable Risk Factors for Alzheimer’s Disease
por: Edwards III, George A., et al.
Publicado: (2019)

Familial Alzheimer’s Disease and Recessive Modifiers
por: Vélez, Jorge I., et al.
Publicado: (2019)

Disease-modifying treatments in Alzheimer’s disease
por: Edwards, Marc, et al.
Publicado: (2023)

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)
por: Pradier, Laurent, et al.
Publicado: (2018)

Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
por: Nieto González, Noelia, et al.
Publicado: (2021)

Lipid metabolism transcriptomics of murine microglia in Alzheimer’s disease and neuroinflammation
por: Shippy, Daniel C., et al.
Publicado: (2023)

Design of a broadly reactive Lyme disease vaccine
por: Kamp, Heather D., et al.
Publicado: (2020)

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity
por: Nguyen, An Phu Tran, et al.
Publicado: (2020)

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
por: Nabel, Christopher S., et al.
Publicado: (2012)

The chemotherapeutic response of a murine (VM) model of human glioma.
por: Bradford, R., et al.
Publicado: (1990)

Modifiable Risk Factors for Alzheimer Disease and Subjective Memory Impairment across Age Groups
por: Chen, Stephen T., et al.
Publicado: (2014)

Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity
por: Durán, Anyelo, et al.
Publicado: (2021)

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease
por: Lu, Xi, et al.
Publicado: (2015)

Microglial response to experimental periodontitis in a murine model of Alzheimer’s disease
por: Kantarci, Alpdogan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1j6h0s69eu5agtbs47s1lgj365