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Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor
Mitochondrial disorders arise from defects in nuclear genes encoding enzymes of oxidative metabolism. Mutations of metabolic enzymes in somatic tissues can cause cancers due to oncometabolite accumulation. Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936837/ https://www.ncbi.nlm.nih.gov/pubmed/31887185 http://dx.doi.org/10.1371/journal.pone.0227033 |