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Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor

Mitochondrial disorders arise from defects in nuclear genes encoding enzymes of oxidative metabolism. Mutations of metabolic enzymes in somatic tissues can cause cancers due to oncometabolite accumulation. Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by...

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Detalles Bibliográficos
Autores principales:	Braun, Megan M., Damjanac, Tamara, Zhang, Yuxia, Chen, Chuan, Hu, Jinghua, Maher, L. James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936837/ https://www.ncbi.nlm.nih.gov/pubmed/31887185 http://dx.doi.org/10.1371/journal.pone.0227033

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