A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport

Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport in the sub-micromolar range, acting via three cellular targe...

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Detalles Bibliográficos
Autores principales: Shlevkov, Evgeny, Basu, Himanish, Bray, Mark-Anthony, Sun, Zheng, Wei, Wei, Apaydin, Kaan, Karhohs, Kyle, Chen, Pin-Fang, Smith, Janell L.M., Wiskow, Ole, Roet, Kasper, Huang, Xuan, Eggan, Kevin, Carpenter, Anne E., Kleiman, Robin J., Schwarz, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937139/
https://www.ncbi.nlm.nih.gov/pubmed/31533043
http://dx.doi.org/10.1016/j.celrep.2019.08.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937139/
https://www.ncbi.nlm.nih.gov/pubmed/31533043
http://dx.doi.org/10.1016/j.celrep.2019.08.035

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