A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants

Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determinat...

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Detalles Bibliográficos
Autores principales: Kweon, Jiyeon, Jang, An-Hee, Shin, Ha Rim, See, Ji-Eun, Lee, Woochang, Lee, Jong Won, Chang, Suhwan, Kim, Kyunggon, Kim, Yongsub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937211/
https://www.ncbi.nlm.nih.gov/pubmed/31467430
http://dx.doi.org/10.1038/s41388-019-0968-2

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