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Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

Resistance of breast cancer to human epidermal growth factor receptor 2 (HER2) inhibitors involves reprogramming of the kinome through HER2/HER3 signaling via the activation of multiple tyrosine kinases and transcriptional upregulation. The heterogeneity of induced kinases prevents kinase targeting...

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Detalles Bibliográficos
Autores principales:	Sun, Bowen, Mason, Seth, Wilson, Robert C., Hazard, Starr E., Wang, Yubao, Fang, Rong, Wang, Qiwei, Yeh, Elizabeth S., Yang, Meixiang, Roberts, Thomas M., Zhao, Jean J., Wang, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937212/ https://www.ncbi.nlm.nih.gov/pubmed/31462705 http://dx.doi.org/10.1038/s41388-019-0953-9

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