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Structured Back Focal Plane Interferometry (SBFPI)
Back focal plane interferometry (BFPI) is one of the most straightforward and powerful methods for achieving sub-nanometer particle tracking precision at high speed (MHz). BFPI faces technical challenges that prohibit tunable expansion of linear detection range with minimal loss to sensitivity, whil...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937250/ https://www.ncbi.nlm.nih.gov/pubmed/31889054 http://dx.doi.org/10.1038/s41598-019-56199-z |
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author | Upadhya, Avinash Zheng, Yujie Li, Li Lee, Woei Ming |
author_facet | Upadhya, Avinash Zheng, Yujie Li, Li Lee, Woei Ming |
author_sort | Upadhya, Avinash |
collection | PubMed |
description | Back focal plane interferometry (BFPI) is one of the most straightforward and powerful methods for achieving sub-nanometer particle tracking precision at high speed (MHz). BFPI faces technical challenges that prohibit tunable expansion of linear detection range with minimal loss to sensitivity, while maintaining robustness against optical aberrations. In this paper, we devise a tunable BFPI combining a structured beam (conical wavefront) and structured detection (annular quadrant photodiode). This technique, which we termed Structured Back Focal Plane Interferometry (SBFPI), possesses three key novelties namely: extended tracking range, low loss in sensitivity, and resilience to spatial aberrations. Most importantly, the conical wavefront beam preserves the axial Gouy phase shift and lateral beam waist that can then be harnessed in a conventional BFPI system. Through a series of experimental results, we were able to tune detection sensitivity and detection range over the SBFPI parameter space. We also identified a figure of merit based on the experimental optimum that allows us to identify optimal SBPFI configurations that balance both range and sensitivity. In addition, we also studied the resilience of SBFPI against asymmetric spatial aberrations (astigmatism of up to 0.8 λ) along the lateral directions. The simplicity and elegance of SBFPI will accelerate its dissemination to many associated fields in optical detection, interferometry and force spectroscopy. |
format | Online Article Text |
id | pubmed-6937250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69372502020-01-06 Structured Back Focal Plane Interferometry (SBFPI) Upadhya, Avinash Zheng, Yujie Li, Li Lee, Woei Ming Sci Rep Article Back focal plane interferometry (BFPI) is one of the most straightforward and powerful methods for achieving sub-nanometer particle tracking precision at high speed (MHz). BFPI faces technical challenges that prohibit tunable expansion of linear detection range with minimal loss to sensitivity, while maintaining robustness against optical aberrations. In this paper, we devise a tunable BFPI combining a structured beam (conical wavefront) and structured detection (annular quadrant photodiode). This technique, which we termed Structured Back Focal Plane Interferometry (SBFPI), possesses three key novelties namely: extended tracking range, low loss in sensitivity, and resilience to spatial aberrations. Most importantly, the conical wavefront beam preserves the axial Gouy phase shift and lateral beam waist that can then be harnessed in a conventional BFPI system. Through a series of experimental results, we were able to tune detection sensitivity and detection range over the SBFPI parameter space. We also identified a figure of merit based on the experimental optimum that allows us to identify optimal SBPFI configurations that balance both range and sensitivity. In addition, we also studied the resilience of SBFPI against asymmetric spatial aberrations (astigmatism of up to 0.8 λ) along the lateral directions. The simplicity and elegance of SBFPI will accelerate its dissemination to many associated fields in optical detection, interferometry and force spectroscopy. Nature Publishing Group UK 2019-12-30 /pmc/articles/PMC6937250/ /pubmed/31889054 http://dx.doi.org/10.1038/s41598-019-56199-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Upadhya, Avinash Zheng, Yujie Li, Li Lee, Woei Ming Structured Back Focal Plane Interferometry (SBFPI) |
title | Structured Back Focal Plane Interferometry (SBFPI) |
title_full | Structured Back Focal Plane Interferometry (SBFPI) |
title_fullStr | Structured Back Focal Plane Interferometry (SBFPI) |
title_full_unstemmed | Structured Back Focal Plane Interferometry (SBFPI) |
title_short | Structured Back Focal Plane Interferometry (SBFPI) |
title_sort | structured back focal plane interferometry (sbfpi) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937250/ https://www.ncbi.nlm.nih.gov/pubmed/31889054 http://dx.doi.org/10.1038/s41598-019-56199-z |
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