Cargando…

Cognition at age 70: Life course predictors and associations with brain pathologies

OBJECTIVE: To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a substudy of the Medical Research Council National Survey of Health...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Kirsty, Nicholas, Jennifer M., Collins, Jessica D., James, Sarah-Naomi, Parker, Thomas D., Lane, Christopher A., Keshavan, Ashvini, Keuss, Sarah E., Buchanan, Sarah M., Murray-Smith, Heidi, Cash, David M., Sudre, Carole H., Malone, Ian B., Coath, William, Wong, Andrew, Henley, Susie M.D., Crutch, Sebastian J., Fox, Nick C., Richards, Marcus, Schott, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937487/ https://www.ncbi.nlm.nih.gov/pubmed/31666352 http://dx.doi.org/10.1212/WNL.0000000000008534

Ejemplares similares

Increased variability in reaction time is associated with amyloid beta pathology at age 70
por: Lu, Kirsty, et al.
Publicado: (2020)

Subjective cognitive complaints at age 70: associations with amyloid and mental health
por: Pavisic, Ivanna M., et al.
Publicado: (2021)

Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort
por: James, Sarah-Naomi, et al.
Publicado: (2023)

Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease
por: Lu, Kirsty, et al.
Publicado: (2021)

Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort
por: Buchanan, Sarah M., et al.
Publicado: (2020)

Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds
por: James, Sarah-Naomi, et al.
Publicado: (2023)

Amyloid β influences the relationship between cortical thickness and vascular load
por: Parker, Thomas D., et al.
Publicado: (2020)

Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
por: Parker, Thomas D., et al.
Publicado: (2019)

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
por: Lane, Christopher A, et al.
Publicado: (2019)

Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort
por: Lane, Christopher A., et al.
Publicado: (2019)

Pure tone audiometry and cerebral pathology in healthy older adults
por: Parker, Thomas, et al.
Publicado: (2020)

Investigating the relationship between BMI across adulthood and late life brain pathologies
por: Lane, Christopher A., et al.
Publicado: (2021)

A population‐based study of head injury, cognitive function and pathological markers
por: James, Sarah‐Naomi, et al.
Publicado: (2021)

Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort
por: Keuss, Sarah E., et al.
Publicado: (2022)

Population-based blood screening for preclinical Alzheimer’s disease in a British birth cohort at age 70
por: Keshavan, Ashvini, et al.
Publicado: (2021)

Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46
por: James, Sarah-Naomi, et al.
Publicado: (2018)

Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort
por: Keuss, Sarah E, et al.
Publicado: (2019)

Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study
por: Wagen, Aaron Z, et al.
Publicado: (2022)

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays
por: Keshavan, Ashvini, et al.
Publicado: (2020)

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays
por: Keshavan, Ashvini, et al.
Publicado: (2021)

Operationalizing the centiloid scale for [(18)F]florbetapir PET studies on PET/MRI
por: Coath, William, et al.
Publicado: (2023)

Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease
por: Green, Rebecca E., et al.
Publicado: (2023)

Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume
por: Salzmann, Antoine, et al.
Publicado: (2021)

(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy
por: Yong, Keir X.X., et al.
Publicado: (2014)

Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study
por: Weston, Philip S J, et al.
Publicado: (2018)

Association between carotid atherosclerosis and brain activation patterns during the Stroop task in older adults: An fNIRS investigation
por: Mason, Sarah A., et al.
Publicado: (2022)

Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles
por: Keshavan, Ashvini, et al.
Publicado: (2018)

Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development
por: Lane, Christopher A., et al.
Publicado: (2017)

Visual short-term memory binding deficit in familial Alzheimer's disease
por: Liang, Yuying, et al.
Publicado: (2016)

ApoE influences regional white-matter axonal density loss in Alzheimer's disease
por: Slattery, Catherine F., et al.
Publicado: (2017)

Prominent effects and neural correlates of visual crowding in a neurodegenerative disease population
por: Yong, Keir X. X., et al.
Publicado: (2014)

Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease
por: Weston, Philip S. J., et al.
Publicado: (2023)

White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration
por: Downey, Laura E., et al.
Publicado: (2015)

Humour processing in frontotemporal lobar degeneration: A behavioural and neuroanatomical analysis
por: Clark, Camilla N., et al.
Publicado: (2015)

Degradation of cognitive timing mechanisms in behavioural variant frontotemporal dementia
por: Henley, Susie M.D., et al.
Publicado: (2014)

Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
por: Parker, Thomas D., et al.
Publicado: (2018)

Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease
por: Novak, Marianne J. U., et al.
Publicado: (2012)

CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia
por: Clarke, Mica T. M., et al.
Publicado: (2019)

Correction to: Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort
por: Dercon, Quentin, et al.
Publicado: (2021)

Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort
por: Dercon, Quentin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_490vckf44qcdhngs066tjojhaf