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Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer

BACKGROUND: Epigenetic regulations play pivotal roles in tumorigenesis and cancer development. Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that catalyzes the mono-, di-, and tri-methylation of lysine 79 histone 3 (H3K79). Howe...

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Detalles Bibliográficos
Autores principales:	Yang, Liqun, Lei, Qian, Li, Lin, Yang, Jie, Dong, Zhen, Cui, Hongjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937672/ https://www.ncbi.nlm.nih.gov/pubmed/31888761 http://dx.doi.org/10.1186/s13148-019-0778-y

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