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INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer’s Symptomatic Expression (INCREASE), a randomized controlled trial: rationale, study design, and protocol

BACKGROUND: The course of Alzheimer’s disease (AD) includes a 10–20-year preclinical period with progressive accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles in the absence of symptomatic cognitive or functional decline. The duration of this preclinical stage in part depends on the...

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Detalles Bibliográficos
Autores principales:	Moga, Daniela C., Beech, Brooke F., Abner, Erin L., Schmitt, Frederick A., El Khouli, Riham H., Martinez, Ashley I., Eckmann, Lynne, Huffmyer, Mark, George, Rosmy, Jicha, Gregory A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937673/ https://www.ncbi.nlm.nih.gov/pubmed/31888732 http://dx.doi.org/10.1186/s13063-019-3993-0

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