LINE-1 ORF2p expression is nearly imperceptible in human cancers

BACKGROUND: Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. Many types of human cancers are characterized by L1 p...

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Detalles Bibliográficos
Autores principales: Ardeljan, Daniel, Wang, Xuya, Oghbaie, Mehrnoosh, Taylor, Martin S., Husband, David, Deshpande, Vikram, Steranka, Jared P., Gorbounov, Mikhail, Yang, Wan Rou, Sie, Brandon, Larman, H. Benjamin, Jiang, Hua, Molloy, Kelly R., Altukhov, Ilya, Li, Zhi, McKerrow, Wilson, Fenyö, David, Burns, Kathleen H., LaCava, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937734/
https://www.ncbi.nlm.nih.gov/pubmed/31892958
http://dx.doi.org/10.1186/s13100-019-0191-2

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