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Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer
BACKGROUND: Our aim is to study if mammographic density (MD) prior to neoadjuvant chemotherapy is a predictive factor in accomplishing a pathological complete response (pCR) in neoadjuvant-treated breast cancer patients. METHODS: Data on all neoadjuvant treated breast cancer patients in Southern Swe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937786/ https://www.ncbi.nlm.nih.gov/pubmed/31888552 http://dx.doi.org/10.1186/s12885-019-6485-4 |
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author | Skarping, Ida Förnvik, Daniel Sartor, Hanna Heide-Jørgensen, Uffe Zackrisson, Sophia Borgquist, Signe |
author_facet | Skarping, Ida Förnvik, Daniel Sartor, Hanna Heide-Jørgensen, Uffe Zackrisson, Sophia Borgquist, Signe |
author_sort | Skarping, Ida |
collection | PubMed |
description | BACKGROUND: Our aim is to study if mammographic density (MD) prior to neoadjuvant chemotherapy is a predictive factor in accomplishing a pathological complete response (pCR) in neoadjuvant-treated breast cancer patients. METHODS: Data on all neoadjuvant treated breast cancer patients in Southern Sweden (2005–2016) were retrospectively identified, with patient and tumor characteristics retrieved from their medical charts. Diagnostic mammograms were used to evaluate and score MD as categorized by breast composition with the Breast Imaging-Reporting and Data System (BI-RADS) 5th edition. Logistic regression was used in complete cases to assess the odds ratios (OR) for pCR compared to BI-RADS categories (a vs b-d), adjusting for patient and pre-treatment tumor characteristics. RESULTS: A total of 302 patients were included in the study population, of which 57 (18.9%) patients accomplished pCR following neoadjuvant chemotherapy. The number of patients in the BI-RADS category a, b, c, and d were separately 16, 120, 140, and 26, respectively. In comparison to patients with BI-RADS breast composition a, patients with denser breasts had a lower OR of accomplishing pCR: BI-RADS b 0.32 (95%CI 0.07–0.1.5), BI-RADS c 0.30 (95%CI 0.06–1.45), and BI-RADS d 0.06 (95%CI 0.01–0.56). These associations were measured with lower point estimates, but wider confidence interval, in premenopausal patients; OR of accomplishing pCR for BI-RADS d in comparison to BI-RADS a: 0.03 (95%CI 0.00–0.76). CONCLUSIONS: The likelihood of accomplishing pCR is indicated to be lower in breast cancer patients with higher MD, which need to be analysed in future studies for improved clinical decision-making regarding neoadjuvant treatment. |
format | Online Article Text |
id | pubmed-6937786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69377862019-12-31 Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer Skarping, Ida Förnvik, Daniel Sartor, Hanna Heide-Jørgensen, Uffe Zackrisson, Sophia Borgquist, Signe BMC Cancer Research Article BACKGROUND: Our aim is to study if mammographic density (MD) prior to neoadjuvant chemotherapy is a predictive factor in accomplishing a pathological complete response (pCR) in neoadjuvant-treated breast cancer patients. METHODS: Data on all neoadjuvant treated breast cancer patients in Southern Sweden (2005–2016) were retrospectively identified, with patient and tumor characteristics retrieved from their medical charts. Diagnostic mammograms were used to evaluate and score MD as categorized by breast composition with the Breast Imaging-Reporting and Data System (BI-RADS) 5th edition. Logistic regression was used in complete cases to assess the odds ratios (OR) for pCR compared to BI-RADS categories (a vs b-d), adjusting for patient and pre-treatment tumor characteristics. RESULTS: A total of 302 patients were included in the study population, of which 57 (18.9%) patients accomplished pCR following neoadjuvant chemotherapy. The number of patients in the BI-RADS category a, b, c, and d were separately 16, 120, 140, and 26, respectively. In comparison to patients with BI-RADS breast composition a, patients with denser breasts had a lower OR of accomplishing pCR: BI-RADS b 0.32 (95%CI 0.07–0.1.5), BI-RADS c 0.30 (95%CI 0.06–1.45), and BI-RADS d 0.06 (95%CI 0.01–0.56). These associations were measured with lower point estimates, but wider confidence interval, in premenopausal patients; OR of accomplishing pCR for BI-RADS d in comparison to BI-RADS a: 0.03 (95%CI 0.00–0.76). CONCLUSIONS: The likelihood of accomplishing pCR is indicated to be lower in breast cancer patients with higher MD, which need to be analysed in future studies for improved clinical decision-making regarding neoadjuvant treatment. BioMed Central 2019-12-30 /pmc/articles/PMC6937786/ /pubmed/31888552 http://dx.doi.org/10.1186/s12885-019-6485-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Skarping, Ida Förnvik, Daniel Sartor, Hanna Heide-Jørgensen, Uffe Zackrisson, Sophia Borgquist, Signe Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title | Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title_full | Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title_fullStr | Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title_full_unstemmed | Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title_short | Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
title_sort | mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937786/ https://www.ncbi.nlm.nih.gov/pubmed/31888552 http://dx.doi.org/10.1186/s12885-019-6485-4 |
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