α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein propagate in cell culture models and in vivo in a prion-like...

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Detalles Bibliográficos
Autores principales: Rey, Nolwen L., Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer A., Melki, Ronald, Brundin, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937797/
https://www.ncbi.nlm.nih.gov/pubmed/31888771
http://dx.doi.org/10.1186/s40478-019-0859-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937797/
https://www.ncbi.nlm.nih.gov/pubmed/31888771
http://dx.doi.org/10.1186/s40478-019-0859-3

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