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Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin

BACKGROUND: The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS: Mosquito collections were performed on a monthly basis using human landing catches an...

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Autores principales: Salako, Albert Sourou, Dagnon, Fortune, Sovi, Arthur, Padonou, Gil Germain, Aïkpon, Rock, Ahogni, Idelphonse, Syme, Thomas, Govoétchan, Renaud, Sagbohan, Herman, Sominahouin, André Aimé, Akinro, Bruno, Iyikirenga, Laurent, Agossa, Fiacre, Akogbeto, Martin Codjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937814/
https://www.ncbi.nlm.nih.gov/pubmed/31888730
http://dx.doi.org/10.1186/s13071-019-3865-1
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author Salako, Albert Sourou
Dagnon, Fortune
Sovi, Arthur
Padonou, Gil Germain
Aïkpon, Rock
Ahogni, Idelphonse
Syme, Thomas
Govoétchan, Renaud
Sagbohan, Herman
Sominahouin, André Aimé
Akinro, Bruno
Iyikirenga, Laurent
Agossa, Fiacre
Akogbeto, Martin Codjo
author_facet Salako, Albert Sourou
Dagnon, Fortune
Sovi, Arthur
Padonou, Gil Germain
Aïkpon, Rock
Ahogni, Idelphonse
Syme, Thomas
Govoétchan, Renaud
Sagbohan, Herman
Sominahouin, André Aimé
Akinro, Bruno
Iyikirenga, Laurent
Agossa, Fiacre
Akogbeto, Martin Codjo
author_sort Salako, Albert Sourou
collection PubMed
description BACKGROUND: The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS: Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray catches in six districts including four treated with Actellic 300 CS (Kandi, Gogounou, Djougou and Copargo) and two untreated (Bembèrèkè and Kouandé) which served as control sites. Key transmission indicators of Anopheles gambiae (s.l.) as well as the residual activity of Actellic 300 CS assessed through WHO cone tests, were determined. RESULTS: The residual efficacy duration of Actellic 300 CS after the two IRS campaigns (2017 and 2018) was 4–5 months (May–September). The parity rate and the sporozoite index of An. gambiae (s.l.) were 36.62% and 0.71%, respectively, after the first spray round in treated areas compared to 57.24% and 3.7%, respectively, in the control areas (P < 0.0001). The same trend was observed after the second spray round. After the first spray round, each person received 1.6 infective bites/month (ib/m) in the treated areas against 12.11 ib/m in the control areas, resulting in a reduction rate of 86.78%. Similarly, the entomological inoculation rate was 1.5 ib/m after the second spray round in the treated areas vs 9.75 ib/m in the control areas, corresponding to a reduction of 84.61%. A decrease in the parity rate (46.26%), sporozoite index (85.75%) and EIR (87.27%) was observed for An. gambiae (s.l.) after the first round of IRS (June–October 2017) compared to the pre-intervention period (June–October 2016). The density of An. gambiae (s.l.) ranged between 0.38–0.48 per house in treated areas vs 1.53–1.76 An. gambiae (s.l.) per house respectively after the first and second IRS rounds. CONCLUSIONS: This study showed the positive impact of IRS in reducing key entomological parameters of malaria transmission in Alibori and Donga. However, the considerable blood-feeding rate of An. gambiae (s.l.) in spray areas, stress the need for the population to sleep under long-lasting insecticidal nets (LLINs) in addition, to prevent from mosquito bites which did not succeed in resting on sprayed walls.
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spelling pubmed-69378142019-12-31 Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin Salako, Albert Sourou Dagnon, Fortune Sovi, Arthur Padonou, Gil Germain Aïkpon, Rock Ahogni, Idelphonse Syme, Thomas Govoétchan, Renaud Sagbohan, Herman Sominahouin, André Aimé Akinro, Bruno Iyikirenga, Laurent Agossa, Fiacre Akogbeto, Martin Codjo Parasit Vectors Research BACKGROUND: The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS: Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray catches in six districts including four treated with Actellic 300 CS (Kandi, Gogounou, Djougou and Copargo) and two untreated (Bembèrèkè and Kouandé) which served as control sites. Key transmission indicators of Anopheles gambiae (s.l.) as well as the residual activity of Actellic 300 CS assessed through WHO cone tests, were determined. RESULTS: The residual efficacy duration of Actellic 300 CS after the two IRS campaigns (2017 and 2018) was 4–5 months (May–September). The parity rate and the sporozoite index of An. gambiae (s.l.) were 36.62% and 0.71%, respectively, after the first spray round in treated areas compared to 57.24% and 3.7%, respectively, in the control areas (P < 0.0001). The same trend was observed after the second spray round. After the first spray round, each person received 1.6 infective bites/month (ib/m) in the treated areas against 12.11 ib/m in the control areas, resulting in a reduction rate of 86.78%. Similarly, the entomological inoculation rate was 1.5 ib/m after the second spray round in the treated areas vs 9.75 ib/m in the control areas, corresponding to a reduction of 84.61%. A decrease in the parity rate (46.26%), sporozoite index (85.75%) and EIR (87.27%) was observed for An. gambiae (s.l.) after the first round of IRS (June–October 2017) compared to the pre-intervention period (June–October 2016). The density of An. gambiae (s.l.) ranged between 0.38–0.48 per house in treated areas vs 1.53–1.76 An. gambiae (s.l.) per house respectively after the first and second IRS rounds. CONCLUSIONS: This study showed the positive impact of IRS in reducing key entomological parameters of malaria transmission in Alibori and Donga. However, the considerable blood-feeding rate of An. gambiae (s.l.) in spray areas, stress the need for the population to sleep under long-lasting insecticidal nets (LLINs) in addition, to prevent from mosquito bites which did not succeed in resting on sprayed walls. BioMed Central 2019-12-30 /pmc/articles/PMC6937814/ /pubmed/31888730 http://dx.doi.org/10.1186/s13071-019-3865-1 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Salako, Albert Sourou
Dagnon, Fortune
Sovi, Arthur
Padonou, Gil Germain
Aïkpon, Rock
Ahogni, Idelphonse
Syme, Thomas
Govoétchan, Renaud
Sagbohan, Herman
Sominahouin, André Aimé
Akinro, Bruno
Iyikirenga, Laurent
Agossa, Fiacre
Akogbeto, Martin Codjo
Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title_full Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title_fullStr Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title_full_unstemmed Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title_short Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin
title_sort efficacy of actellic 300 cs-based indoor residual spraying on key entomological indicators of malaria transmission in alibori and donga, two regions of northern benin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937814/
https://www.ncbi.nlm.nih.gov/pubmed/31888730
http://dx.doi.org/10.1186/s13071-019-3865-1
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