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Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. To investigate the role of pyruvate kinase in pan...

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Detalles Bibliográficos
Autores principales:	Yu, Lei, Teoh, Shao Thing, Ensink, Elliot, Ogrodzinski, Martin P., Yang, Che, Vazquez, Ana I., Lunt, Sophia Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937848/ https://www.ncbi.nlm.nih.gov/pubmed/31893043 http://dx.doi.org/10.1186/s40170-019-0205-z

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