TNF-α mediated upregulation of Na(V)1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

Clinical and preclinical studies have shown that patients with Diabetic Neuropathy Pain (DNP) present with increased tumor necrosis factor alpha (TNF-α) serum concentration, whereas studies with diabetic animals have shown that TNF-α induces an increase in Na(V)1.7 sodium channel expression. This is...

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Detalles Bibliográficos
Autores principales: de Macedo, Flávio Henrique Pequeno, Aires, Rosária Dias, Fonseca, Esdras Guedes, Ferreira, Renata Cristina Mendes, Machado, Daniel Portela Dias, Chen, Lina, Zhang, Fang-Xiong, Souza, Ivana A., Lemos, Virgínia Soares, Romero, Thiago Roberto Lima, Moutal, Aubin, Khanna, Rajesh, Zamponi, Gerald W., Cruz, Jader S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937926/
https://www.ncbi.nlm.nih.gov/pubmed/31888677
http://dx.doi.org/10.1186/s13041-019-0538-0

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