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Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India

BACKGROUND: Cohort studies are pivotal in understanding the natural history, and to thereby determine the incidence of a disease. The conduct of large-scale community-based cohort studies is challenging with reference to money, manpower and time. Further, attrition inherent to cohort studies can aff...

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Autores principales: Sindhu, Kulandaipalayam Natarajan, Srinivasan, Manikandan, Subramaniam, Sathyapriya, David, Anita Shirley, Mohan, Venkata Raghava, John, Jacob, Kang, Gagandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937945/
https://www.ncbi.nlm.nih.gov/pubmed/31888513
http://dx.doi.org/10.1186/s12874-019-0881-y
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author Sindhu, Kulandaipalayam Natarajan
Srinivasan, Manikandan
Subramaniam, Sathyapriya
David, Anita Shirley
Mohan, Venkata Raghava
John, Jacob
Kang, Gagandeep
author_facet Sindhu, Kulandaipalayam Natarajan
Srinivasan, Manikandan
Subramaniam, Sathyapriya
David, Anita Shirley
Mohan, Venkata Raghava
John, Jacob
Kang, Gagandeep
author_sort Sindhu, Kulandaipalayam Natarajan
collection PubMed
description BACKGROUND: Cohort studies are pivotal in understanding the natural history, and to thereby determine the incidence of a disease. The conduct of large-scale community-based cohort studies is challenging with reference to money, manpower and time. Further, attrition inherent to cohort studies can affect the power, and thereby the study’s validity. Our objective was to estimate the percentage of participant withdrawal and to subsequently understand reasons for the same in the Vellore Typhoid Surveillance (VTS) cohort. METHODS: VTS study, a prospective community-based pediatric cohort, was established in a semi-urban settlement of Vellore to estimate the incidence rate of typhoid fever. An active weekly surveillance identified children with fever, and blood cultures were performed for fevers of ≥3 days. Reasons for participant drop-out in the cohort were documented. Nine focus group discussions (FGD), each with 5 to 7 parents/primary caregivers of former as well current participants were conducted separately, to understand reasons for consent withdrawal as well as the good aspects of the study that the current participants perceived. A descriptive, as well as an interpretative account of the themes that emerged from the FGDs were done. RESULTS: Of the 5639 children in the VTS cohort, 404 (7.2%) withdrew consent during the 12-month surveillance. Of these, 50% dropped out due to migration from study area; 18.1% as their parents were unhappy with the blood draws for blood culture; and 14.4% did not clearly put forth the reason for consent withdrawal. Being from an orthodox background, high socio-economic status and joint family were associated with a decision to drop-out. Frequent and voluminous blood draws, male field research assistants (FRA) making weekly home-visits, the perception that inquiring about fever made their child fall sick, and that the study clinic did not initiate antibiotics immediately, were the important themes that emerged from the FGDs conducted among drop-outs. CONCLUSION: Our study showed that specific beliefs and behaviours within the community influenced the drop-out rate of the VTS cohort. Background characteristics and perceptions that exist, along with attrition data from previous cohort studies in the specific community are important to be considered while implementing large-scale cohort studies.
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spelling pubmed-69379452019-12-31 Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India Sindhu, Kulandaipalayam Natarajan Srinivasan, Manikandan Subramaniam, Sathyapriya David, Anita Shirley Mohan, Venkata Raghava John, Jacob Kang, Gagandeep BMC Med Res Methodol Research Article BACKGROUND: Cohort studies are pivotal in understanding the natural history, and to thereby determine the incidence of a disease. The conduct of large-scale community-based cohort studies is challenging with reference to money, manpower and time. Further, attrition inherent to cohort studies can affect the power, and thereby the study’s validity. Our objective was to estimate the percentage of participant withdrawal and to subsequently understand reasons for the same in the Vellore Typhoid Surveillance (VTS) cohort. METHODS: VTS study, a prospective community-based pediatric cohort, was established in a semi-urban settlement of Vellore to estimate the incidence rate of typhoid fever. An active weekly surveillance identified children with fever, and blood cultures were performed for fevers of ≥3 days. Reasons for participant drop-out in the cohort were documented. Nine focus group discussions (FGD), each with 5 to 7 parents/primary caregivers of former as well current participants were conducted separately, to understand reasons for consent withdrawal as well as the good aspects of the study that the current participants perceived. A descriptive, as well as an interpretative account of the themes that emerged from the FGDs were done. RESULTS: Of the 5639 children in the VTS cohort, 404 (7.2%) withdrew consent during the 12-month surveillance. Of these, 50% dropped out due to migration from study area; 18.1% as their parents were unhappy with the blood draws for blood culture; and 14.4% did not clearly put forth the reason for consent withdrawal. Being from an orthodox background, high socio-economic status and joint family were associated with a decision to drop-out. Frequent and voluminous blood draws, male field research assistants (FRA) making weekly home-visits, the perception that inquiring about fever made their child fall sick, and that the study clinic did not initiate antibiotics immediately, were the important themes that emerged from the FGDs conducted among drop-outs. CONCLUSION: Our study showed that specific beliefs and behaviours within the community influenced the drop-out rate of the VTS cohort. Background characteristics and perceptions that exist, along with attrition data from previous cohort studies in the specific community are important to be considered while implementing large-scale cohort studies. BioMed Central 2019-12-30 /pmc/articles/PMC6937945/ /pubmed/31888513 http://dx.doi.org/10.1186/s12874-019-0881-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sindhu, Kulandaipalayam Natarajan
Srinivasan, Manikandan
Subramaniam, Sathyapriya
David, Anita Shirley
Mohan, Venkata Raghava
John, Jacob
Kang, Gagandeep
Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title_full Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title_fullStr Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title_full_unstemmed Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title_short Why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at Vellore, southern India
title_sort why do participants drop-out: findings from a prospective pediatric cohort for fever surveillance established at vellore, southern india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937945/
https://www.ncbi.nlm.nih.gov/pubmed/31888513
http://dx.doi.org/10.1186/s12874-019-0881-y
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