Increased Ca(2+) signaling in NRXN1α(+/−) neurons derived from ASD induced pluripotent stem cells

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia, intellectual disability, epilepsy, and developm...

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Detalles Bibliográficos
Autores principales: Avazzadeh, Sahar, McDonagh, Katya, Reilly, Jamie, Wang, Yanqin, Boomkamp, Stephanie D., McInerney, Veronica, Krawczyk, Janusz, Fitzgerald, Jacqueline, Feerick, Niamh, O’Sullivan, Matthew, Jalali, Amirhossein, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Cosemans, Nele, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Quinlan, Leo R., Gallagher, Louise, Shen, Sanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937972/
https://www.ncbi.nlm.nih.gov/pubmed/31893021
http://dx.doi.org/10.1186/s13229-019-0303-3

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