Cargando…

“Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”

BACKGROUND: A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Mardian, Yan, Yano, Yoshihiko, Ratnasari, Neneng, Choridah, Lina, Wasityastuti, Widya, Setyawan, Nurhuda Hendra, Hayashi, Yoshitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937974/
https://www.ncbi.nlm.nih.gov/pubmed/31888500
http://dx.doi.org/10.1186/s12876-019-1152-4
_version_ 1783483979701157888
author Mardian, Yan
Yano, Yoshihiko
Ratnasari, Neneng
Choridah, Lina
Wasityastuti, Widya
Setyawan, Nurhuda Hendra
Hayashi, Yoshitake
author_facet Mardian, Yan
Yano, Yoshihiko
Ratnasari, Neneng
Choridah, Lina
Wasityastuti, Widya
Setyawan, Nurhuda Hendra
Hayashi, Yoshitake
author_sort Mardian, Yan
collection PubMed
description BACKGROUND: A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients. METHODS: SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis. RESULTS: Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm(2)/m(2) for men and ≤ 29.6 cm(2)/m(2) for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤ 39.3 HU for women). These groups had shorter median survival than the reference groups (both P < 0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P < 0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P < 0.01 and HR: 6.131, P < 0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P < 0.001) were independently associated with mortality. CONCLUSION: Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes. (Electric word counts: 249).
format Online
Article
Text
id pubmed-6937974
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-69379742019-12-31 “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study” Mardian, Yan Yano, Yoshihiko Ratnasari, Neneng Choridah, Lina Wasityastuti, Widya Setyawan, Nurhuda Hendra Hayashi, Yoshitake BMC Gastroenterol Research Article BACKGROUND: A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Japanese patients. METHODS: SMI and mean muscle attenuation (MA) were evaluated using computed tomography images of the third lumbar vertebra (L3) in a prospective cohort of 100 Indonesian HCC patients. Clinical, laboratory and body composition data were analysed using the Kaplan–Meier method and Cox regression model to investigate which factors are associated with prognosis. RESULTS: Of 100 patients, 31 were diagnosed with sarcopenia (L3 SMI value ≤36.2 cm(2)/m(2) for men and ≤ 29.6 cm(2)/m(2) for women), and 65 had IMF deposition (MA value ≤44.4 HU for men and ≤ 39.3 HU for women). These groups had shorter median survival than the reference groups (both P < 0.0001). In multivariable analysis, sarcopenia (hazard ratio [HR], 1.921; P = 0.016), IMF deposition (HR, 3.580; P < 0.001), Barcelona Clinic Liver Cancer (BCLC) stages C and D (HR: 2.396, P < 0.01 and HR: 6.131, P < 0.01, respectively), Japan Integrated Staging (JIS) score 4 (HR: 2.067, P = 0.020), and male gender (HR: 3.211, P < 0.001) were independently associated with mortality. CONCLUSION: Sarcopenia and IMF deposition showed superior value in combination with BCLC stage and JIS score for predicting the survival of Indonesian HCC patients. Increased awareness and strategies to prevent or reverse these factors might improve patient outcomes. (Electric word counts: 249). BioMed Central 2019-12-30 /pmc/articles/PMC6937974/ /pubmed/31888500 http://dx.doi.org/10.1186/s12876-019-1152-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Mardian, Yan
Yano, Yoshihiko
Ratnasari, Neneng
Choridah, Lina
Wasityastuti, Widya
Setyawan, Nurhuda Hendra
Hayashi, Yoshitake
“Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title_full “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title_fullStr “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title_full_unstemmed “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title_short “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”
title_sort “sarcopenia and intramuscular fat deposition are associated with poor survival in indonesian patients with hepatocellular carcinoma: a retrospective study”
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937974/
https://www.ncbi.nlm.nih.gov/pubmed/31888500
http://dx.doi.org/10.1186/s12876-019-1152-4
work_keys_str_mv AT mardianyan sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT yanoyoshihiko sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT ratnasarineneng sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT choridahlina sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT wasityastutiwidya sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT setyawannurhudahendra sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy
AT hayashiyoshitake sarcopeniaandintramuscularfatdepositionareassociatedwithpoorsurvivalinindonesianpatientswithhepatocellularcarcinomaaretrospectivestudy