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Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects

Loss-of-function mutations in the nonconventional myosin Vb (Myo5b) result in microvillus inclusion disease (MVID) and massive secretory diarrhea that often begins at birth. Myo5b mutations disrupt the apical recycling endosome (ARE) and membrane traffic, resulting in reduced surface expression of a...

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Detalles Bibliográficos
Autores principales:	Forteza, Radia, Ahsan, M. Kaimul, Cartón-García, Fernando, Arango, Diego, Ameen, Nadia A., Salas, Pedro J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938243/ https://www.ncbi.nlm.nih.gov/pubmed/31664880 http://dx.doi.org/10.1091/mbc.E18-07-0415

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