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Tankyrase inhibition sensitizes cells to CDK4 blockade

Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited anti-proliferative activity as a monotherapy in hum...

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Detalles Bibliográficos
Autores principales:	Foronda, Miguel, Tarumoto, Yusuke, Schatoff, Emma M., Leach, Benjamin I., Diaz, Bianca J., Zimmerman, Jill, Goswami, Sukanya, Shusterman, Michael, Vakoc, Christopher R., Dow, Lukas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938305/ https://www.ncbi.nlm.nih.gov/pubmed/31891587 http://dx.doi.org/10.1371/journal.pone.0226645

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