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Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?

INTRODUCTION: Studies have revealed that glycated albumin (GA) is a useful alternative to HbA(1c) under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2...

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Autores principales: Chume, Fernando Chimela, Kieling, Mayana Hernandez, Correa Freitas, Priscila Aparecida, Cavagnolli, Gabriela, Camargo, Joíza Lins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938306/
https://www.ncbi.nlm.nih.gov/pubmed/31891628
http://dx.doi.org/10.1371/journal.pone.0227065
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author Chume, Fernando Chimela
Kieling, Mayana Hernandez
Correa Freitas, Priscila Aparecida
Cavagnolli, Gabriela
Camargo, Joíza Lins
author_facet Chume, Fernando Chimela
Kieling, Mayana Hernandez
Correa Freitas, Priscila Aparecida
Cavagnolli, Gabriela
Camargo, Joíza Lins
author_sort Chume, Fernando Chimela
collection PubMed
description INTRODUCTION: Studies have revealed that glycated albumin (GA) is a useful alternative to HbA(1c) under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus (DM). Thus, the aim of this study was to assess the clinical utility of GA in diagnosis of DM. MATERIALS AND METHODS: This diagnostic test accuracy study was performed in 242 Brazilian individuals referred for OGTT in a tertiary university hospital. ROC curves were used to access the performance of GA and HbA(1c) in the diagnosis of DM by oral glucose tolerance test (OGTT). RESULTS: OGTT, HbA(1c) and GA were performed in all 242 participants (40.5% male, age 54.4 ± 13.0 years [mean ± SD], body mass index 28.9 ± 6.3 kg/m(2)). DM by OGTT was detected in 31.8% of individuals. The equilibrium threshold value of GA ≥14.8% showed sensitivity of 64.9% and specificity of 65.5% for the diagnosis of DM. The AUC for GA [0.703 (95% CI 0.631–0.775)] was lower than for HbA(1c) [0.802 (95% CI 0.740–0.864)], p = 0.028. A GA value of 16.8% had similar accuracy for detecting DM as defined by HbA(1c) ≥6.5% (48 mmol/mol) with sensitivity of 31.2% and specificity of 93.3% for both tests. However, GA detects different subjects from those detected by HbA(1c) and OGTT. CONCLUSIONS: GA detected different individuals with DM from those detected by HbA(1c), though it showed overall diagnostic accuracy similar to HbA(1c) in the diagnosis of DM. Therefore, GA should be used as an additional test rather than an alternative to HbA(1c) or OGTT and its use as the sole DM diagnostic test should be interpreted with caution.
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spelling pubmed-69383062020-01-07 Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test? Chume, Fernando Chimela Kieling, Mayana Hernandez Correa Freitas, Priscila Aparecida Cavagnolli, Gabriela Camargo, Joíza Lins PLoS One Research Article INTRODUCTION: Studies have revealed that glycated albumin (GA) is a useful alternative to HbA(1c) under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus (DM). Thus, the aim of this study was to assess the clinical utility of GA in diagnosis of DM. MATERIALS AND METHODS: This diagnostic test accuracy study was performed in 242 Brazilian individuals referred for OGTT in a tertiary university hospital. ROC curves were used to access the performance of GA and HbA(1c) in the diagnosis of DM by oral glucose tolerance test (OGTT). RESULTS: OGTT, HbA(1c) and GA were performed in all 242 participants (40.5% male, age 54.4 ± 13.0 years [mean ± SD], body mass index 28.9 ± 6.3 kg/m(2)). DM by OGTT was detected in 31.8% of individuals. The equilibrium threshold value of GA ≥14.8% showed sensitivity of 64.9% and specificity of 65.5% for the diagnosis of DM. The AUC for GA [0.703 (95% CI 0.631–0.775)] was lower than for HbA(1c) [0.802 (95% CI 0.740–0.864)], p = 0.028. A GA value of 16.8% had similar accuracy for detecting DM as defined by HbA(1c) ≥6.5% (48 mmol/mol) with sensitivity of 31.2% and specificity of 93.3% for both tests. However, GA detects different subjects from those detected by HbA(1c) and OGTT. CONCLUSIONS: GA detected different individuals with DM from those detected by HbA(1c), though it showed overall diagnostic accuracy similar to HbA(1c) in the diagnosis of DM. Therefore, GA should be used as an additional test rather than an alternative to HbA(1c) or OGTT and its use as the sole DM diagnostic test should be interpreted with caution. Public Library of Science 2019-12-31 /pmc/articles/PMC6938306/ /pubmed/31891628 http://dx.doi.org/10.1371/journal.pone.0227065 Text en © 2019 Chume et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chume, Fernando Chimela
Kieling, Mayana Hernandez
Correa Freitas, Priscila Aparecida
Cavagnolli, Gabriela
Camargo, Joíza Lins
Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title_full Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title_fullStr Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title_full_unstemmed Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title_short Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
title_sort glycated albumin as a diagnostic tool in diabetes: an alternative or an additional test?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938306/
https://www.ncbi.nlm.nih.gov/pubmed/31891628
http://dx.doi.org/10.1371/journal.pone.0227065
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