A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans

We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the Metabochip and hundreds of phenotypes in 5,897 African...

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Detalles Bibliográficos
Autores principales: Pendergrass, Sarah A., Buyske, Steven, Jeff, Janina M., Frase, Alex, Dudek, Scott, Bradford, Yuki, Ambite, Jose-Luis, Avery, Christy L., Buzkova, Petra, Deelman, Ewa, Fesinmeyer, Megan D., Haiman, Christopher, Heiss, Gerardo, Hindorff, Lucia A., Hsu, Chun-Nan, Jackson, Rebecca D., Lin, Yi, Le Marchand, Loic, Matise, Tara C., Monroe, Kristine R., Moreland, Larry, North, Kari E., Park, Sungshim L., Reiner, Alex, Wallace, Robert, Wilkens, Lynne R., Kooperberg, Charles, Ritchie, Marylyn D., Crawford, Dana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938343/
https://www.ncbi.nlm.nih.gov/pubmed/31891604
http://dx.doi.org/10.1371/journal.pone.0226771

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