Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

An increasingly appreciated conundrum in the discovery of antibody drug conjugates (ADCs) is that an antibody that was selected primarily for strong binding to its cancer target may not serve as an optimal ADC. In this study, we performed mechanistic cell-based experiments to determine the correlati...

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Detalles Bibliográficos
Autores principales: Zwaagstra, John C., Sulea, Traian, Baardsnes, Jason, Radinovic, Stevo, Cepero-Donates, Yuneivy, Robert, Alma, O’Connor-McCourt, Maureen D., Tikhomirov, Ilia A., Jaramillo, Maria Luz.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938348/
https://www.ncbi.nlm.nih.gov/pubmed/31891584
http://dx.doi.org/10.1371/journal.pone.0226593

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