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Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention

One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not relieved by sleep. We have modeled exertional...

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Autores principales: Clarke, Tomas, Jamieson, Jessie D., Malone, Patrick, Rayhan, Rakib U., Washington, Stuart, VanMeter, John W., Baraniuk, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938369/
https://www.ncbi.nlm.nih.gov/pubmed/31891592
http://dx.doi.org/10.1371/journal.pone.0226481
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author Clarke, Tomas
Jamieson, Jessie D.
Malone, Patrick
Rayhan, Rakib U.
Washington, Stuart
VanMeter, John W.
Baraniuk, James N.
author_facet Clarke, Tomas
Jamieson, Jessie D.
Malone, Patrick
Rayhan, Rakib U.
Washington, Stuart
VanMeter, John W.
Baraniuk, James N.
author_sort Clarke, Tomas
collection PubMed
description One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not relieved by sleep. We have modeled exertional exhaustion by comparing magnetic resonance images from before and after submaximal exercise. One third of the 27 GWI participants had brain stem atrophy and developed postural tachycardia after exercise (START: Stress Test Activated Reversible Tachycardia). The remainder activated basal ganglia and anterior insulae during a cognitive task (STOPP: Stress Test Originated Phantom Perception). Here, the role of attention in cognitive dysfunction was assessed by seed region correlations during a simple 0-back stimulus matching task (“see a letter, push a button”) performed before exercise. Analysis was analogous to resting state, but different from psychophysiological interactions (PPI). The patterns of correlations between nodes in task and default networks were significantly different for START (n = 9), STOPP (n = 18) and control (n = 8) subjects. Edges shared by the 3 groups may represent co-activation caused by the 0-back task. Controls had a task network of right dorsolateral and left ventrolateral prefrontal cortex, dorsal anterior cingulate cortex, posterior insulae and frontal eye fields (dorsal attention network). START had a large task module centered on the dorsal anterior cingulate cortex with direct links to basal ganglia, anterior insulae, and right dorsolateral prefrontal cortex nodes, and through dorsal attention network (intraparietal sulci and frontal eye fields) nodes to a default module. STOPP had 2 task submodules of basal ganglia–anterior insulae, and dorsolateral prefrontal executive control regions. Dorsal attention and posterior insulae nodes were embedded in the default module and were distant from the task networks. These three unique connectivity patterns during an attention task support the concept of Gulf War Disease with recognizable, objective patterns of cognitive dysfunction.
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spelling pubmed-69383692020-01-07 Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention Clarke, Tomas Jamieson, Jessie D. Malone, Patrick Rayhan, Rakib U. Washington, Stuart VanMeter, John W. Baraniuk, James N. PLoS One Research Article One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not relieved by sleep. We have modeled exertional exhaustion by comparing magnetic resonance images from before and after submaximal exercise. One third of the 27 GWI participants had brain stem atrophy and developed postural tachycardia after exercise (START: Stress Test Activated Reversible Tachycardia). The remainder activated basal ganglia and anterior insulae during a cognitive task (STOPP: Stress Test Originated Phantom Perception). Here, the role of attention in cognitive dysfunction was assessed by seed region correlations during a simple 0-back stimulus matching task (“see a letter, push a button”) performed before exercise. Analysis was analogous to resting state, but different from psychophysiological interactions (PPI). The patterns of correlations between nodes in task and default networks were significantly different for START (n = 9), STOPP (n = 18) and control (n = 8) subjects. Edges shared by the 3 groups may represent co-activation caused by the 0-back task. Controls had a task network of right dorsolateral and left ventrolateral prefrontal cortex, dorsal anterior cingulate cortex, posterior insulae and frontal eye fields (dorsal attention network). START had a large task module centered on the dorsal anterior cingulate cortex with direct links to basal ganglia, anterior insulae, and right dorsolateral prefrontal cortex nodes, and through dorsal attention network (intraparietal sulci and frontal eye fields) nodes to a default module. STOPP had 2 task submodules of basal ganglia–anterior insulae, and dorsolateral prefrontal executive control regions. Dorsal attention and posterior insulae nodes were embedded in the default module and were distant from the task networks. These three unique connectivity patterns during an attention task support the concept of Gulf War Disease with recognizable, objective patterns of cognitive dysfunction. Public Library of Science 2019-12-31 /pmc/articles/PMC6938369/ /pubmed/31891592 http://dx.doi.org/10.1371/journal.pone.0226481 Text en © 2019 Clarke et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Clarke, Tomas
Jamieson, Jessie D.
Malone, Patrick
Rayhan, Rakib U.
Washington, Stuart
VanMeter, John W.
Baraniuk, James N.
Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title_full Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title_fullStr Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title_full_unstemmed Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title_short Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
title_sort connectivity differences between gulf war illness (gwi) phenotypes during a test of attention
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938369/
https://www.ncbi.nlm.nih.gov/pubmed/31891592
http://dx.doi.org/10.1371/journal.pone.0226481
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