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Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases
The largest outbreak of yellow fever of the 21(st) century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of São Paulo city (MRSP) during 2017–2018. Her...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938505/ https://www.ncbi.nlm.nih.gov/pubmed/31892699 http://dx.doi.org/10.1038/s41598-019-56650-1 |
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author | Cunha, Marielton dos Passos Duarte-Neto, Amaro Nunes Pour, Shahab Zaki Ortiz-Baez, Ayda Susana Černý, Jiří Pereira, Bárbara Brito de Souza Braconi, Carla Torres Ho, Yeh-Li Perondi, Beatriz Sztajnbok, Jaques Alves, Venancio Avancini Ferreira Dolhnikoff, Marisa Holmes, Edward C. Saldiva, Paulo Hilário Nascimento Zanotto, Paolo Marinho de Andrade |
author_facet | Cunha, Marielton dos Passos Duarte-Neto, Amaro Nunes Pour, Shahab Zaki Ortiz-Baez, Ayda Susana Černý, Jiří Pereira, Bárbara Brito de Souza Braconi, Carla Torres Ho, Yeh-Li Perondi, Beatriz Sztajnbok, Jaques Alves, Venancio Avancini Ferreira Dolhnikoff, Marisa Holmes, Edward C. Saldiva, Paulo Hilário Nascimento Zanotto, Paolo Marinho de Andrade |
author_sort | Cunha, Marielton dos Passos |
collection | PubMed |
description | The largest outbreak of yellow fever of the 21(st) century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of São Paulo city (MRSP) during 2017–2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus (YFV) during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil (Minas Gerais, Espírito Santo, Bahia and Rio de Janeiro states). Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri-urban area without detectable human-to-human transmission, and towards the Atlantic rain forest causing human spill-over in nearby cities, yet in the absence of sustained viral transmission in the urban environment. |
format | Online Article Text |
id | pubmed-6938505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69385052020-01-06 Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases Cunha, Marielton dos Passos Duarte-Neto, Amaro Nunes Pour, Shahab Zaki Ortiz-Baez, Ayda Susana Černý, Jiří Pereira, Bárbara Brito de Souza Braconi, Carla Torres Ho, Yeh-Li Perondi, Beatriz Sztajnbok, Jaques Alves, Venancio Avancini Ferreira Dolhnikoff, Marisa Holmes, Edward C. Saldiva, Paulo Hilário Nascimento Zanotto, Paolo Marinho de Andrade Sci Rep Article The largest outbreak of yellow fever of the 21(st) century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of São Paulo city (MRSP) during 2017–2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus (YFV) during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil (Minas Gerais, Espírito Santo, Bahia and Rio de Janeiro states). Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri-urban area without detectable human-to-human transmission, and towards the Atlantic rain forest causing human spill-over in nearby cities, yet in the absence of sustained viral transmission in the urban environment. Nature Publishing Group UK 2019-12-31 /pmc/articles/PMC6938505/ /pubmed/31892699 http://dx.doi.org/10.1038/s41598-019-56650-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cunha, Marielton dos Passos Duarte-Neto, Amaro Nunes Pour, Shahab Zaki Ortiz-Baez, Ayda Susana Černý, Jiří Pereira, Bárbara Brito de Souza Braconi, Carla Torres Ho, Yeh-Li Perondi, Beatriz Sztajnbok, Jaques Alves, Venancio Avancini Ferreira Dolhnikoff, Marisa Holmes, Edward C. Saldiva, Paulo Hilário Nascimento Zanotto, Paolo Marinho de Andrade Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title | Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title_full | Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title_fullStr | Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title_full_unstemmed | Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title_short | Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
title_sort | origin of the são paulo yellow fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938505/ https://www.ncbi.nlm.nih.gov/pubmed/31892699 http://dx.doi.org/10.1038/s41598-019-56650-1 |
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