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Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism
BACKGROUND: Pseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in the GNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies acc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938634/ https://www.ncbi.nlm.nih.gov/pubmed/31892351 http://dx.doi.org/10.1186/s12903-019-0978-z |
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author | Hejlesen, Jane Underbjerg, Line Gjørup, Hans Sikjaer, Tanja Rejnmark, Lars Haubek, Dorte |
author_facet | Hejlesen, Jane Underbjerg, Line Gjørup, Hans Sikjaer, Tanja Rejnmark, Lars Haubek, Dorte |
author_sort | Hejlesen, Jane |
collection | PubMed |
description | BACKGROUND: Pseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in the GNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies according to tooth types and the orthodontic characteristics of patients with PHP. METHODS: Using a cross-sectional design, 29 patients (23 females) with PHP, living in Denmark, were included, and their clinical intraoral photos and radiographs were examined. RESULTS: Pulp calcification was found in 76% of the patients. Blunting of root apex was present in 55% and shortening of root in 48% of the examined patients. Blunting and shortening of roots were seen more often in premolars than in other tooth types (p(both) < 0.01). Crowding of lower anterior teeth was frequently observed (36%) as well as diastema in the upper arch (25%), midline diastema (18%), and Class III malocclusion (11%). CONCLUSION: In the present study population, the teeth were frequently affected by pulp calcification and/or deviation of the root morphology. Blunting and shortening of root(s) were more often seen in premolars than in other tooth types. Class III malocclusion was relatively prevalent. It is important to pay attention to dental anomalies and occlusion in order to provide adequate care for patients with PHP. |
format | Online Article Text |
id | pubmed-6938634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69386342020-01-06 Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism Hejlesen, Jane Underbjerg, Line Gjørup, Hans Sikjaer, Tanja Rejnmark, Lars Haubek, Dorte BMC Oral Health Research Article BACKGROUND: Pseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in the GNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies according to tooth types and the orthodontic characteristics of patients with PHP. METHODS: Using a cross-sectional design, 29 patients (23 females) with PHP, living in Denmark, were included, and their clinical intraoral photos and radiographs were examined. RESULTS: Pulp calcification was found in 76% of the patients. Blunting of root apex was present in 55% and shortening of root in 48% of the examined patients. Blunting and shortening of roots were seen more often in premolars than in other tooth types (p(both) < 0.01). Crowding of lower anterior teeth was frequently observed (36%) as well as diastema in the upper arch (25%), midline diastema (18%), and Class III malocclusion (11%). CONCLUSION: In the present study population, the teeth were frequently affected by pulp calcification and/or deviation of the root morphology. Blunting and shortening of root(s) were more often seen in premolars than in other tooth types. Class III malocclusion was relatively prevalent. It is important to pay attention to dental anomalies and occlusion in order to provide adequate care for patients with PHP. BioMed Central 2019-12-31 /pmc/articles/PMC6938634/ /pubmed/31892351 http://dx.doi.org/10.1186/s12903-019-0978-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Hejlesen, Jane Underbjerg, Line Gjørup, Hans Sikjaer, Tanja Rejnmark, Lars Haubek, Dorte Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title | Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title_full | Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title_fullStr | Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title_full_unstemmed | Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title_short | Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
title_sort | dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938634/ https://www.ncbi.nlm.nih.gov/pubmed/31892351 http://dx.doi.org/10.1186/s12903-019-0978-z |
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