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Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome

BACKGROUND: Acute coronary syndrome (ACS) occurs approximately every 40 seconds, and was an underlying cause of death in 1 out of every 7 deaths. More accurate indicators are needed to distinguish patients with ACS from patients manifesting negative changes in electrocardiogram (ECG) and myocardial...

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Autores principales: Wan, Wen, Ye, Yujia, Wang, Huawei, Li, Longjun, Gu, Yajuan, Yang, Lai, Yang, Lihong, Liu, Han, Meng, Chao, Li, Deng, Wang, Zhe, Meng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938652/
https://www.ncbi.nlm.nih.gov/pubmed/31865362
http://dx.doi.org/10.12659/MSM.918913
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author Wan, Wen
Ye, Yujia
Wang, Huawei
Li, Longjun
Gu, Yajuan
Yang, Lai
Yang, Lihong
Liu, Han
Meng, Chao
Li, Deng
Wang, Zhe
Meng, Zhaohui
author_facet Wan, Wen
Ye, Yujia
Wang, Huawei
Li, Longjun
Gu, Yajuan
Yang, Lai
Yang, Lihong
Liu, Han
Meng, Chao
Li, Deng
Wang, Zhe
Meng, Zhaohui
author_sort Wan, Wen
collection PubMed
description BACKGROUND: Acute coronary syndrome (ACS) occurs approximately every 40 seconds, and was an underlying cause of death in 1 out of every 7 deaths. More accurate indicators are needed to distinguish patients with ACS from patients manifesting negative changes in electrocardiogram (ECG) and myocardial enzymes. This study aimed to investigate whether the expression of platelet carcinoembryonic antigen cell adhesion molecule-5 (CEACAM5/CEA/CD66e) could help predict ACS. MATERIAL/METHODS: We enrolled 82 participants (mean age 60 years, 33 females and 49 males). The expression of CEA on washed human platelets was assessed using two-color flow cytometry. The CEA levels on platelets and in serum of these 82 consecutive patients were detected using two-color whole-blood flow cytometry analysis and a custom-made Luminex multiplex assay, respectively. RESULTS: CEA was expressed on the surface of human platelets. The expression of platelet CEA (P<0.01), but not serum CEA (P=0.30), was significantly higher in patients with ACS compared to patients with normal coronary artery. Increased platelet CEA levels could serve as a new independent indicator for ACS (P=0.0003). Platelet CEA testing (P=0.000002), as well as cardiac troponin I (cTnI) (P=0.0005), can diagnose ACS with high sensitivity and specificity, and, combined with cTnI (P<0.0001), can improve the diagnostic value. CONCLUSIONS: Platelet CEA expression was higher in individuals presenting with ACS. Hence, platelet CEA might be a novel and reliable biomarker for ACS. Large-scale studies are needed to confirm this hypothesis.
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spelling pubmed-69386522020-01-09 Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome Wan, Wen Ye, Yujia Wang, Huawei Li, Longjun Gu, Yajuan Yang, Lai Yang, Lihong Liu, Han Meng, Chao Li, Deng Wang, Zhe Meng, Zhaohui Med Sci Monit Clinical Research BACKGROUND: Acute coronary syndrome (ACS) occurs approximately every 40 seconds, and was an underlying cause of death in 1 out of every 7 deaths. More accurate indicators are needed to distinguish patients with ACS from patients manifesting negative changes in electrocardiogram (ECG) and myocardial enzymes. This study aimed to investigate whether the expression of platelet carcinoembryonic antigen cell adhesion molecule-5 (CEACAM5/CEA/CD66e) could help predict ACS. MATERIAL/METHODS: We enrolled 82 participants (mean age 60 years, 33 females and 49 males). The expression of CEA on washed human platelets was assessed using two-color flow cytometry. The CEA levels on platelets and in serum of these 82 consecutive patients were detected using two-color whole-blood flow cytometry analysis and a custom-made Luminex multiplex assay, respectively. RESULTS: CEA was expressed on the surface of human platelets. The expression of platelet CEA (P<0.01), but not serum CEA (P=0.30), was significantly higher in patients with ACS compared to patients with normal coronary artery. Increased platelet CEA levels could serve as a new independent indicator for ACS (P=0.0003). Platelet CEA testing (P=0.000002), as well as cardiac troponin I (cTnI) (P=0.0005), can diagnose ACS with high sensitivity and specificity, and, combined with cTnI (P<0.0001), can improve the diagnostic value. CONCLUSIONS: Platelet CEA expression was higher in individuals presenting with ACS. Hence, platelet CEA might be a novel and reliable biomarker for ACS. Large-scale studies are needed to confirm this hypothesis. International Scientific Literature, Inc. 2019-12-22 /pmc/articles/PMC6938652/ /pubmed/31865362 http://dx.doi.org/10.12659/MSM.918913 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Wan, Wen
Ye, Yujia
Wang, Huawei
Li, Longjun
Gu, Yajuan
Yang, Lai
Yang, Lihong
Liu, Han
Meng, Chao
Li, Deng
Wang, Zhe
Meng, Zhaohui
Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title_full Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title_fullStr Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title_full_unstemmed Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title_short Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
title_sort platelet carcinoembryonic antigen cell adhesion molecule 5 (ceacam5) as a possible novel diagnostic tool for evaluation of acute coronary syndrome
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938652/
https://www.ncbi.nlm.nih.gov/pubmed/31865362
http://dx.doi.org/10.12659/MSM.918913
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