Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

In this study, we investigated the roles of Epac1 in pathological angiogenesis and its potential as a novel therapeutic target for the treatment of vasoproliferative diseases. Genetic deletion of Epac1 ameliorated pathological angiogenesis in mouse models of oxygen-induced retinopathy (OIR) and caro...

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Detalles Bibliográficos
Autores principales: Liu, Hua, Mei, Fang C., Yang, Wenli, Wang, Hui, Wong, Eitan, Cai, Jingjing, Toth, Emma, Luo, Pei, Li, Yue-Ming, Zhang, Wenbo, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938696/
https://www.ncbi.nlm.nih.gov/pubmed/31911948
http://dx.doi.org/10.1126/sciadv.aay3566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938696/
https://www.ncbi.nlm.nih.gov/pubmed/31911948
http://dx.doi.org/10.1126/sciadv.aay3566

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