Control of protein function through oxidation and reduction of persulfidated states

Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein function. We found that persulfidation (CysSSH) protects Cys from irreversible oxidative loss of function by the formation of CysSSO(1-3)H derivatives that can subsequently be reduced back to native thiols. R...

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Detalles Bibliográficos
Autores principales: Dóka, É., Ida, T., Dagnell, M., Abiko, Y., Luong, N. C., Balog, N., Takata, T., Espinosa, B., Nishimura, A., Cheng, Q., Funato, Y., Miki, H., Fukuto, J. M., Prigge, J. R., Schmidt, E. E., Arnér, E. S. J., Kumagai, Y., Akaike, T., Nagy, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938701/
https://www.ncbi.nlm.nih.gov/pubmed/31911946
http://dx.doi.org/10.1126/sciadv.aax8358

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