Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells

To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AH...

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Autores principales: Leem, Galam, Kim, Beom Kyung, Shin, Eui-Cheol, Park, Jun Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938783/
https://www.ncbi.nlm.nih.gov/pubmed/31887806
http://dx.doi.org/10.3349/ymj.2020.61.1.100
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author Leem, Galam
Kim, Beom Kyung
Shin, Eui-Cheol
Park, Jun Yong
author_facet Leem, Galam
Kim, Beom Kyung
Shin, Eui-Cheol
Park, Jun Yong
author_sort Leem, Galam
collection PubMed
description To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
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spelling pubmed-69387832020-01-06 Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells Leem, Galam Kim, Beom Kyung Shin, Eui-Cheol Park, Jun Yong Yonsei Med J Brief Communication To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA. Yonsei University College of Medicine 2020-01-01 2019-12-23 /pmc/articles/PMC6938783/ /pubmed/31887806 http://dx.doi.org/10.3349/ymj.2020.61.1.100 Text en © Copyright: Yonsei University College of Medicine 2020 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Leem, Galam
Kim, Beom Kyung
Shin, Eui-Cheol
Park, Jun Yong
Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title_full Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title_fullStr Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title_full_unstemmed Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title_short Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
title_sort autoimmune hepatic failure following acute hepatitis a is accompanied by inflammatory conversion of regulatory t cells
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938783/
https://www.ncbi.nlm.nih.gov/pubmed/31887806
http://dx.doi.org/10.3349/ymj.2020.61.1.100
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AT shineuicheol autoimmunehepaticfailurefollowingacutehepatitisaisaccompaniedbyinflammatoryconversionofregulatorytcells
AT parkjunyong autoimmunehepaticfailurefollowingacutehepatitisaisaccompaniedbyinflammatoryconversionofregulatorytcells

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