The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients

BACKGROUND: In colorectal cancer, hPG80 (progastrin) is released from tumor cells, promotes cancer stem cells (CSC) self-renewal and is detected in the blood of patients. Because the gene GAST that encodes hPG80 is a target gene of oncogenic pathways that are activated in many tumor types, we hypoth...

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Detalles Bibliográficos
Autores principales: You, Benoit, Mercier, Frédéric, Assenat, Eric, Langlois-Jacques, Carole, Glehen, Olivier, Soulé, Julien, Payen, Léa, Kepenekian, Vahan, Dupuy, Marie, Belouin, Fanny, Morency, Eric, Saywell, Véronique, Flacelière, Maud, Elies, Philippe, Liaud, Pierre, Mazard, Thibault, Maucort-Boulch, Delphine, Tan, Winston, Vire, Bérengère, Villeneuve, Laurent, Ychou, Marc, Kohli, Manish, Joubert, Dominique, Prieur, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938867/
https://www.ncbi.nlm.nih.gov/pubmed/31877416
http://dx.doi.org/10.1016/j.ebiom.2019.11.035

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