Epigenetic Regulation of m(6)A Modifications in Human Cancer

N6-methyladenosine (m(6)A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m(6)A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m(6)A modifications are catalyzed by RNA methyltransferases, such as...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Wei, Qi, Xiaoqian, Liu, Lina, Liu, Zihao, Ma, Shiqing, Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938965/
https://www.ncbi.nlm.nih.gov/pubmed/31887551
http://dx.doi.org/10.1016/j.omtn.2019.11.022
_version_ 1783484140504481792
author Zhao, Wei
Qi, Xiaoqian
Liu, Lina
Liu, Zihao
Ma, Shiqing
Wu, Jie
author_facet Zhao, Wei
Qi, Xiaoqian
Liu, Lina
Liu, Zihao
Ma, Shiqing
Wu, Jie
author_sort Zhao, Wei
collection PubMed
description N6-methyladenosine (m(6)A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m(6)A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m(6)A modifications are catalyzed by RNA methyltransferases, such as METTL3, METTL14, and WTAP (writers); the modifications are removed by the demethylases fat mass and obesity-associated protein (FTO) and ALKBH5 (ALKB homolog 5) (erasers); and the modifications are recognized by m(6)A-binding proteins, such as YTHDF domain-containing proteins and IGF2BPs (readers). Abnormal changes in the m(6)A levels of these genes are closely related to tumor occurrence and development. In this paper, we review the role of m(6)A in human cancer and summarize its prospective applications in cancer.
format Online
Article
Text
id pubmed-6938965
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Society of Gene & Cell Therapy
record_format MEDLINE/PubMed
spelling pubmed-69389652020-01-06 Epigenetic Regulation of m(6)A Modifications in Human Cancer Zhao, Wei Qi, Xiaoqian Liu, Lina Liu, Zihao Ma, Shiqing Wu, Jie Mol Ther Nucleic Acids Article N6-methyladenosine (m(6)A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m(6)A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m(6)A modifications are catalyzed by RNA methyltransferases, such as METTL3, METTL14, and WTAP (writers); the modifications are removed by the demethylases fat mass and obesity-associated protein (FTO) and ALKBH5 (ALKB homolog 5) (erasers); and the modifications are recognized by m(6)A-binding proteins, such as YTHDF domain-containing proteins and IGF2BPs (readers). Abnormal changes in the m(6)A levels of these genes are closely related to tumor occurrence and development. In this paper, we review the role of m(6)A in human cancer and summarize its prospective applications in cancer. American Society of Gene & Cell Therapy 2019-11-29 /pmc/articles/PMC6938965/ /pubmed/31887551 http://dx.doi.org/10.1016/j.omtn.2019.11.022 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhao, Wei
Qi, Xiaoqian
Liu, Lina
Liu, Zihao
Ma, Shiqing
Wu, Jie
Epigenetic Regulation of m(6)A Modifications in Human Cancer
title Epigenetic Regulation of m(6)A Modifications in Human Cancer
title_full Epigenetic Regulation of m(6)A Modifications in Human Cancer
title_fullStr Epigenetic Regulation of m(6)A Modifications in Human Cancer
title_full_unstemmed Epigenetic Regulation of m(6)A Modifications in Human Cancer
title_short Epigenetic Regulation of m(6)A Modifications in Human Cancer
title_sort epigenetic regulation of m(6)a modifications in human cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938965/
https://www.ncbi.nlm.nih.gov/pubmed/31887551
http://dx.doi.org/10.1016/j.omtn.2019.11.022
work_keys_str_mv AT zhaowei epigeneticregulationofm6amodificationsinhumancancer
AT qixiaoqian epigeneticregulationofm6amodificationsinhumancancer
AT liulina epigeneticregulationofm6amodificationsinhumancancer
AT liuzihao epigeneticregulationofm6amodificationsinhumancancer
AT mashiqing epigeneticregulationofm6amodificationsinhumancancer
AT wujie epigeneticregulationofm6amodificationsinhumancancer

Ejemplares similares