Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggest...

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Detalles Bibliográficos
Autores principales: Steiner, Kevin L, Kabir, Mamun, Priest, Jeffrey W, Hossain, Biplob, Gilchrist, Carol A, Cook, Heather, Ma, Jennie Z, Korpe, Poonum S, Ahmed, Tahmeed, Faruque, A S G, Haque, Rashidul, Petri, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938969/
https://www.ncbi.nlm.nih.gov/pubmed/31131855
http://dx.doi.org/10.1093/cid/ciz430
Descripción
Sumario:In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

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