Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggest...

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Autores principales: Steiner, Kevin L, Kabir, Mamun, Priest, Jeffrey W, Hossain, Biplob, Gilchrist, Carol A, Cook, Heather, Ma, Jennie Z, Korpe, Poonum S, Ahmed, Tahmeed, Faruque, A S G, Haque, Rashidul, Petri, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938969/
https://www.ncbi.nlm.nih.gov/pubmed/31131855
http://dx.doi.org/10.1093/cid/ciz430
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author Steiner, Kevin L
Kabir, Mamun
Priest, Jeffrey W
Hossain, Biplob
Gilchrist, Carol A
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Tahmeed
Faruque, A S G
Haque, Rashidul
Petri, William A
author_facet Steiner, Kevin L
Kabir, Mamun
Priest, Jeffrey W
Hossain, Biplob
Gilchrist, Carol A
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Tahmeed
Faruque, A S G
Haque, Rashidul
Petri, William A
author_sort Steiner, Kevin L
collection PubMed
description In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.
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spelling pubmed-69389692020-01-07 Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study Steiner, Kevin L Kabir, Mamun Priest, Jeffrey W Hossain, Biplob Gilchrist, Carol A Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Tahmeed Faruque, A S G Haque, Rashidul Petri, William A Clin Infect Dis Brief Reports In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children. Oxford University Press 2020-01-15 2019-05-25 /pmc/articles/PMC6938969/ /pubmed/31131855 http://dx.doi.org/10.1093/cid/ciz430 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Steiner, Kevin L
Kabir, Mamun
Priest, Jeffrey W
Hossain, Biplob
Gilchrist, Carol A
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Tahmeed
Faruque, A S G
Haque, Rashidul
Petri, William A
Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title_full Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title_fullStr Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title_full_unstemmed Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title_short Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
title_sort fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban bangladesh: a prospective cohort study
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938969/
https://www.ncbi.nlm.nih.gov/pubmed/31131855
http://dx.doi.org/10.1093/cid/ciz430
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