Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or strok...

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Detalles Bibliográficos
Autores principales: Knutsson, Anki, Björkbacka, Harry, Dunér, Pontus, Engström, Gunnar, Binder, Christoph J., Nilsson, Anna Hultgårdh, Nilsson, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939009/
https://www.ncbi.nlm.nih.gov/pubmed/31909299
http://dx.doi.org/10.1016/j.jacbts.2019.07.002
Descripción
Sumario:Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe(−/−) mice suggesting a protective role for IL-5 in plaque development.

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