Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and progression towards heart failure. This study characterized...

Descripción completa

Detalles Bibliográficos
Autores principales: García, Ricardo A., Ito, Bruce R., Lupisella, John A., Carson, Nancy A., Hsu, Mei-Yin, Fernando, Gayani, Heroux, Madeleine, Bouvier, Michel, Dierks, Elizabeth, Kick, Ellen K., Gordon, David A., Chen, Jian, Mintier, Gabe, Carrier, Marilyn, St-Onge, Stéphane, Shah, Himanshu, Towne, Jordan, Bucardo, Marcela Sotelo, Ma, Xiuying, Ryan, Carol S., Wurtz, Nicholas R., Ostrowski, Jacek, Villarreal, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939031/
https://www.ncbi.nlm.nih.gov/pubmed/31909300
http://dx.doi.org/10.1016/j.jacbts.2019.07.005
_version_ 1783484154205175808
author García, Ricardo A.
Ito, Bruce R.
Lupisella, John A.
Carson, Nancy A.
Hsu, Mei-Yin
Fernando, Gayani
Heroux, Madeleine
Bouvier, Michel
Dierks, Elizabeth
Kick, Ellen K.
Gordon, David A.
Chen, Jian
Mintier, Gabe
Carrier, Marilyn
St-Onge, Stéphane
Shah, Himanshu
Towne, Jordan
Bucardo, Marcela Sotelo
Ma, Xiuying
Ryan, Carol S.
Wurtz, Nicholas R.
Ostrowski, Jacek
Villarreal, Francisco J.
author_facet García, Ricardo A.
Ito, Bruce R.
Lupisella, John A.
Carson, Nancy A.
Hsu, Mei-Yin
Fernando, Gayani
Heroux, Madeleine
Bouvier, Michel
Dierks, Elizabeth
Kick, Ellen K.
Gordon, David A.
Chen, Jian
Mintier, Gabe
Carrier, Marilyn
St-Onge, Stéphane
Shah, Himanshu
Towne, Jordan
Bucardo, Marcela Sotelo
Ma, Xiuying
Ryan, Carol S.
Wurtz, Nicholas R.
Ostrowski, Jacek
Villarreal, Francisco J.
author_sort García, Ricardo A.
collection PubMed
description Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and progression towards heart failure. This study characterized the cellular and signaling properties of Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, and examined whether Cmpd43 treatment improves LV and infarct remodeling in rodent MI models. Cmpd43 stimulated FPR1/2-mediated signaling, enhanced proresolution cellular function, and modulated cytokines. Cmpd43 increased LV function and reduced chamber remodeling while increasing proresolution macrophage markers. The findings demonstrate that FPR agonism improves cardiac structure and function post-MI.
format Online
Article
Text
id pubmed-6939031
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-69390312020-01-06 Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment García, Ricardo A. Ito, Bruce R. Lupisella, John A. Carson, Nancy A. Hsu, Mei-Yin Fernando, Gayani Heroux, Madeleine Bouvier, Michel Dierks, Elizabeth Kick, Ellen K. Gordon, David A. Chen, Jian Mintier, Gabe Carrier, Marilyn St-Onge, Stéphane Shah, Himanshu Towne, Jordan Bucardo, Marcela Sotelo Ma, Xiuying Ryan, Carol S. Wurtz, Nicholas R. Ostrowski, Jacek Villarreal, Francisco J. JACC Basic Transl Sci PRECLINICAL RESEARCH Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and progression towards heart failure. This study characterized the cellular and signaling properties of Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, and examined whether Cmpd43 treatment improves LV and infarct remodeling in rodent MI models. Cmpd43 stimulated FPR1/2-mediated signaling, enhanced proresolution cellular function, and modulated cytokines. Cmpd43 increased LV function and reduced chamber remodeling while increasing proresolution macrophage markers. The findings demonstrate that FPR agonism improves cardiac structure and function post-MI. Elsevier 2019-11-13 /pmc/articles/PMC6939031/ /pubmed/31909300 http://dx.doi.org/10.1016/j.jacbts.2019.07.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
García, Ricardo A.
Ito, Bruce R.
Lupisella, John A.
Carson, Nancy A.
Hsu, Mei-Yin
Fernando, Gayani
Heroux, Madeleine
Bouvier, Michel
Dierks, Elizabeth
Kick, Ellen K.
Gordon, David A.
Chen, Jian
Mintier, Gabe
Carrier, Marilyn
St-Onge, Stéphane
Shah, Himanshu
Towne, Jordan
Bucardo, Marcela Sotelo
Ma, Xiuying
Ryan, Carol S.
Wurtz, Nicholas R.
Ostrowski, Jacek
Villarreal, Francisco J.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title_full Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title_fullStr Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title_full_unstemmed Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title_short Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
title_sort preservation of post-infarction cardiac structure and function via long-term oral formyl peptide receptor agonist treatment
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939031/
https://www.ncbi.nlm.nih.gov/pubmed/31909300
http://dx.doi.org/10.1016/j.jacbts.2019.07.005
work_keys_str_mv AT garciaricardoa preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT itobrucer preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT lupisellajohna preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT carsonnancya preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT hsumeiyin preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT fernandogayani preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT herouxmadeleine preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT bouviermichel preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT dierkselizabeth preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT kickellenk preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT gordondavida preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT chenjian preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT mintiergabe preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT carriermarilyn preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT stongestephane preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT shahhimanshu preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT townejordan preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT bucardomarcelasotelo preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT maxiuying preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT ryancarols preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT wurtznicholasr preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT ostrowskijacek preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment
AT villarrealfranciscoj preservationofpostinfarctioncardiacstructureandfunctionvialongtermoralformylpeptidereceptoragonisttreatment

Ejemplares similares