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Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network

A growing number of recent studies has suggested that the neuroplastic effects of electroconvulsive therapy (ECT) might be prominent enough to be detected through changes of regional gray matter volumes (GMV) during the course of the treatment. Given that ECT patients are difficult to recruit for im...

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Autores principales: Camilleri, Julia A., Hoffstaedter, Felix, Zavorotny, Maxim, Zöllner, Rebecca, Wolf, Robert Christian, Thomann, Philipp, Redlich, Ronny, Opel, Nils, Dannlowski, Udo, Groezinger, Michael, Demirakca, Traute, Sartorius, Alexander, Eickhoff, Simon B., Nickl-Jockschat, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939059/
https://www.ncbi.nlm.nih.gov/pubmed/31884221
http://dx.doi.org/10.1016/j.nicl.2019.102114
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author Camilleri, Julia A.
Hoffstaedter, Felix
Zavorotny, Maxim
Zöllner, Rebecca
Wolf, Robert Christian
Thomann, Philipp
Redlich, Ronny
Opel, Nils
Dannlowski, Udo
Groezinger, Michael
Demirakca, Traute
Sartorius, Alexander
Eickhoff, Simon B.
Nickl-Jockschat, Thomas
author_facet Camilleri, Julia A.
Hoffstaedter, Felix
Zavorotny, Maxim
Zöllner, Rebecca
Wolf, Robert Christian
Thomann, Philipp
Redlich, Ronny
Opel, Nils
Dannlowski, Udo
Groezinger, Michael
Demirakca, Traute
Sartorius, Alexander
Eickhoff, Simon B.
Nickl-Jockschat, Thomas
author_sort Camilleri, Julia A.
collection PubMed
description A growing number of recent studies has suggested that the neuroplastic effects of electroconvulsive therapy (ECT) might be prominent enough to be detected through changes of regional gray matter volumes (GMV) during the course of the treatment. Given that ECT patients are difficult to recruit for imaging studies, most publications, however, report only on small samples. Addressing this challenge, we here report results of a structural imaging study on ECT patients that pooled patients from five German sites. Whole-brain voxel-based morphometry (VBM) analysis was performed to detect structural differences in 85 patients with unipolar depression before and after ECT, when compared to 86 healthy controls. Both task-independent and task-dependent physiological whole-brain functional connectivity patterns of these regions were modeled using additional data from healthy subjects. All emerging regions were additionally functionally characterized using the BrainMap database. Our VBM analysis detected a significant increase of GMV in the right hippocampus/amygdala region in patients after ECT compared to healthy controls. In healthy subjects this region was found to be enrolled in a network associated with emotional processing and memory. A region in the left fusiform gyrus was additionally found to have higher GMV in controls when compared with patients at baseline. This region showed minor changes after ECT. Our data points to a GMV increase in patients post ECT in regions that seem to constitute a hub of an emotion processing network. This appears as a plausible antidepressant mechanism and could explain the efficacy of ECT not only in the treatment of unipolar depression, but also of affective symptoms across heterogeneous disorders.
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spelling pubmed-69390592020-01-06 Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network Camilleri, Julia A. Hoffstaedter, Felix Zavorotny, Maxim Zöllner, Rebecca Wolf, Robert Christian Thomann, Philipp Redlich, Ronny Opel, Nils Dannlowski, Udo Groezinger, Michael Demirakca, Traute Sartorius, Alexander Eickhoff, Simon B. Nickl-Jockschat, Thomas Neuroimage Clin Regular Article A growing number of recent studies has suggested that the neuroplastic effects of electroconvulsive therapy (ECT) might be prominent enough to be detected through changes of regional gray matter volumes (GMV) during the course of the treatment. Given that ECT patients are difficult to recruit for imaging studies, most publications, however, report only on small samples. Addressing this challenge, we here report results of a structural imaging study on ECT patients that pooled patients from five German sites. Whole-brain voxel-based morphometry (VBM) analysis was performed to detect structural differences in 85 patients with unipolar depression before and after ECT, when compared to 86 healthy controls. Both task-independent and task-dependent physiological whole-brain functional connectivity patterns of these regions were modeled using additional data from healthy subjects. All emerging regions were additionally functionally characterized using the BrainMap database. Our VBM analysis detected a significant increase of GMV in the right hippocampus/amygdala region in patients after ECT compared to healthy controls. In healthy subjects this region was found to be enrolled in a network associated with emotional processing and memory. A region in the left fusiform gyrus was additionally found to have higher GMV in controls when compared with patients at baseline. This region showed minor changes after ECT. Our data points to a GMV increase in patients post ECT in regions that seem to constitute a hub of an emotion processing network. This appears as a plausible antidepressant mechanism and could explain the efficacy of ECT not only in the treatment of unipolar depression, but also of affective symptoms across heterogeneous disorders. Elsevier 2019-12-09 /pmc/articles/PMC6939059/ /pubmed/31884221 http://dx.doi.org/10.1016/j.nicl.2019.102114 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Camilleri, Julia A.
Hoffstaedter, Felix
Zavorotny, Maxim
Zöllner, Rebecca
Wolf, Robert Christian
Thomann, Philipp
Redlich, Ronny
Opel, Nils
Dannlowski, Udo
Groezinger, Michael
Demirakca, Traute
Sartorius, Alexander
Eickhoff, Simon B.
Nickl-Jockschat, Thomas
Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title_full Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title_fullStr Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title_full_unstemmed Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title_short Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
title_sort electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939059/
https://www.ncbi.nlm.nih.gov/pubmed/31884221
http://dx.doi.org/10.1016/j.nicl.2019.102114
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