Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()

Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year...

Descripción completa

Detalles Bibliográficos
Autores principales: Resende, Ludimila Oliveira, Jorge, Marilia Formentini Scotton, Schmitt, Juliano Vilaverde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939081/
https://www.ncbi.nlm.nih.gov/pubmed/31789267
http://dx.doi.org/10.1016/j.abd.2018.12.001
_version_ 1783484165756289024
author Resende, Ludimila Oliveira
Jorge, Marilia Formentini Scotton
Schmitt, Juliano Vilaverde
author_facet Resende, Ludimila Oliveira
Jorge, Marilia Formentini Scotton
Schmitt, Juliano Vilaverde
author_sort Resende, Ludimila Oliveira
collection PubMed
description Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year-old girl with cutaneous ulcers comparable with pyoderma gangrenosum, growth failure and chronic anemia, who was given the diagnosis of hyperzincemia and hypercalprotectinemia. Measurement of serum zinc and calprotectin concentrations are indicated in these cases.
format Online
Article
Text
id pubmed-6939081
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Sociedade Brasileira de Dermatologia
record_format MEDLINE/PubMed
spelling pubmed-69390812020-01-06 Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()() Resende, Ludimila Oliveira Jorge, Marilia Formentini Scotton Schmitt, Juliano Vilaverde An Bras Dermatol Case Report Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year-old girl with cutaneous ulcers comparable with pyoderma gangrenosum, growth failure and chronic anemia, who was given the diagnosis of hyperzincemia and hypercalprotectinemia. Measurement of serum zinc and calprotectin concentrations are indicated in these cases. Sociedade Brasileira de Dermatologia 2019 2019-10-26 /pmc/articles/PMC6939081/ /pubmed/31789267 http://dx.doi.org/10.1016/j.abd.2018.12.001 Text en © 2019 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Resende, Ludimila Oliveira
Jorge, Marilia Formentini Scotton
Schmitt, Juliano Vilaverde
Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title_full Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title_fullStr Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title_full_unstemmed Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title_short Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
title_sort extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?()()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939081/
https://www.ncbi.nlm.nih.gov/pubmed/31789267
http://dx.doi.org/10.1016/j.abd.2018.12.001
work_keys_str_mv AT resendeludimilaoliveira extensivepyodermagangrenosumlikelesionsrevealingacaseofhyperzincemiaandhypercalprotectinemiawhentosuspectit
AT jorgemariliaformentiniscotton extensivepyodermagangrenosumlikelesionsrevealingacaseofhyperzincemiaandhypercalprotectinemiawhentosuspectit
AT schmittjulianovilaverde extensivepyodermagangrenosumlikelesionsrevealingacaseofhyperzincemiaandhypercalprotectinemiawhentosuspectit

Ejemplares similares