Cargando…

IRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells

PURPOSE: Karyopherin alpha 2 (KPNA2) has been reported as an oncogenic protein in numerous human cancers and is currently considered a potential therapeutic target. However, the transcriptional regulation and physiological conditions underlying KPNA2 expression remain unclear. The aim of the present...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Jie-Xin, Wu, Yi-Cheng, Cheng, Ya-Yun, Wang, Chih-Liang, Yu, Chia-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939401/ https://www.ncbi.nlm.nih.gov/pubmed/31920336 http://dx.doi.org/10.2147/OTT.S221832

Ejemplares similares

IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Development of Osteosarcoma
por: Xia, Shuchi, et al.
Publicado: (2022)

USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2
por: Cai, Zeng, et al.
Publicado: (2020)

Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7
por: Duan, Jihui, et al.
Publicado: (2017)

Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7
por: Duan, Jihui, et al.
Publicado: (2016)

SMARCC1 Enters the Nucleus via KPNA2 and Plays an Oncogenic Role in Bladder Cancer
por: Wei, Zhengmao, et al.
Publicado: (2022)

Oncogenic KPNA2 Serves as a Biomarker and Immune Infiltration in Patients With HPV Positive Tongue Squamous Cell Carcinoma
por: Gao, Li, et al.
Publicado: (2022)

IRF4 as an Oncogenic Master Transcription Factor
por: Wong, Regina Wan Ju, et al.
Publicado: (2022)

Hypoxia‐inducible microRNA‐210 regulates the DIMT1‐IRF4 oncogenic axis in multiple myeloma
por: Ikeda, Sho, et al.
Publicado: (2017)

Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1‐STAT1 loop in lung adenocarcinoma
por: Liao, Wei‐Chao, et al.
Publicado: (2021)

mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells
por: Wang, Chun-I, et al.
Publicado: (2016)

KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc
por: Li, Jie, et al.
Publicado: (2018)

KPNA3 Confers Sorafenib Resistance to Advanced Hepatocellular Carcinoma via TWIST Regulated Epithelial-Mesenchymal Transition
por: Hu, Bo, et al.
Publicado: (2019)

Systematic Characterization of the Clinical Relevance of KPNA4 in Pancreatic Ductal Adenocarcinoma
por: Bao, Jingpiao, et al.
Publicado: (2022)

SNHG8 is upregulated in esophageal squamous cell carcinoma and directly sponges microRNA-411 to increase oncogenicity by upregulating KPNA2
por: Song, Huali, et al.
Publicado: (2019)

Downregulation of KPNA2 in non-small-cell lung cancer is associated with Oct4 expression
por: Li, Xiao-Lei, et al.
Publicado: (2013)

SNHG8 is Upregulated in Esophageal Squamous Cell Carcinoma and Directly Sponges microRNA-411 to Increase Oncogenicity by Upregulating KPNA2 [Retraction]
Publicado: (2021)

KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation
por: Jia, Yujie, et al.
Publicado: (2022)

Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2
por: Nakanishi, Anna, et al.
Publicado: (2022)

Corrigendum: Systematic characterization of the clinical relevance of KPNA4 in pancreatic ductal adenocarcinoma
por: Bao, Jingpiao, et al.
Publicado: (2023)

ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling
por: Chen, Yan, et al.
Publicado: (2023)

MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer
por: Liang, Chen, et al.
Publicado: (2017)

Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
por: Feldman, Andrew L., et al.
Publicado: (2008)

Integrative bioinformatics analysis of KPNA2 in six major human cancers
por: Xu, Chaobo, et al.
Publicado: (2021)

Value of KPNA4 as a diagnostic and prognostic biomarker for hepatocellular carcinoma
por: Xu, Mingxing, et al.
Publicado: (2021)

Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis
por: Liu, Na, et al.
Publicado: (2021)

MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer
por: Tsai, Ming-Ming, et al.
Publicado: (2016)

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas
por: Bandini, Cecilia, et al.
Publicado: (2018)

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
por: Christiansen, Anders, et al.
Publicado: (2013)

KPNA2 promotes renal cell carcinoma proliferation and metastasis via NPM
por: Zheng, Song, et al.
Publicado: (2021)

The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth
por: Niu, Fubiao, et al.
Publicado: (2020)

Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis
por: Zhou, Li-Na, et al.
Publicado: (2016)

KPNA3 Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence
por: Morris, Charles P., et al.
Publicado: (2012)

Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma
por: Wang, Hongjun, et al.
Publicado: (2015)

Multiomics-based analyses of KPNA2 highlight its multiple potentials in hepatocellular carcinoma
por: Zhang, Jinzhong, et al.
Publicado: (2021)

Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets
por: Alnoumas, Layla, et al.
Publicado: (2022)

Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2
por: Tan, Sheng, et al.
Publicado: (2014)

Oncogenic switching of hypoxia signalling pathways
por: Ratcliffe, Peter J
Publicado: (2014)

Aberrant expression of KPNA2 is associated with a poor prognosis and contributes to OCT4 nuclear transportation in bladder cancer
por: Zhou, Jingcheng, et al.
Publicado: (2016)

CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression: The role of the CREB1/miR-495-3p/KPNA2 axis in melanoma progression
por: Geng, Xuerui, et al.
Publicado: (2022)

LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3
por: Liu, Tianyou, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_g6fnutqes07klvojten386e9c7