Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

A promising approach for the treatment of nonalcoholic steatohepatitis (NASH) is the inhibition of enhanced hepatic de novo lipogenesis (DNL), which is the synthesis of fatty acids from nonlipid sources. This study assesses three approaches to DNL suppression in a newly developed dietary NASH mouse...

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Detalles Bibliográficos
Autores principales: Gapp, Berangere, Jourdain, Marie, Bringer, Pauline, Kueng, Benjamin, Weber, Delphine, Osmont, Arnaud, Zurbruegg, Stefan, Knehr, Judith, Falchetto, Rocco, Roma, Guglielmo, Dietrich, William, Valdez, Reginald, Beckmann, Nicolau, Nigsch, Florian, Sanyal, Arun J., Ksiazek, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939503/
https://www.ncbi.nlm.nih.gov/pubmed/31909359
http://dx.doi.org/10.1002/hep4.1443

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