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Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, res...

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Detalles Bibliográficos
Autores principales:	Demir, Salih, Boldrin, Elena, Sun, Qian, Hampp, Stephanie, Tausch, Eugen, Eckert, Cornelia, Ebinger, Martin, Handgretinger, Rupert, te Kronnie, Geertruy, Wiesmüller, Lisa, Stilgenbauer, Stephan, Selivanova, Galina, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939517/ https://www.ncbi.nlm.nih.gov/pubmed/31073076 http://dx.doi.org/10.3324/haematol.2018.199364

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