The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis

The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftment of leukemic stem cells. We hypothesized that no...

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Detalles Bibliográficos
Autores principales: Godavarthy, Parimala Sonika, Kumar, Rahul, Herkt, Stefanie C., Pereira, Raquel S., Hayduk, Nina, Weissenberger, Eva S., Aggoune, Djamel, Manavski, Yosif, Lucas, Tina, Pan, Kuan-Ting, Voutsinas, Jenna M., Wu, Qian, Müller, Martin C., Saussele, Susanne, Oellerich, Thomas, Oehler, Vivian G., Lausen, Joern, Krause, Daniela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939533/
https://www.ncbi.nlm.nih.gov/pubmed/31018977
http://dx.doi.org/10.3324/haematol.2018.212365

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