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Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors

Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H(2)O(2)), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptor-mediated ROS generation for physiological signalin...

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Autores principales: Lee, Sae Rom, An, Eun Jung, Kim, Jaesang, Bae, Yun Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939690/
https://www.ncbi.nlm.nih.gov/pubmed/31875663
http://dx.doi.org/10.4062/biomolther.2019.188
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author Lee, Sae Rom
An, Eun Jung
Kim, Jaesang
Bae, Yun Soo
author_facet Lee, Sae Rom
An, Eun Jung
Kim, Jaesang
Bae, Yun Soo
author_sort Lee, Sae Rom
collection PubMed
description Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H(2)O(2)), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptor-mediated ROS generation for physiological signaling processes involved in cell growth, differentiation, apoptosis, and fibrosis. Detectable intracellular levels of ROS can be induced by the electron leakage from mitochondrial respiratory chain as well as by activation of cytochrome p450, glucose oxidase and xanthine oxidase, leading to oxidative stress. The up-regulation and the hyper-activation of NADPH oxidases (Nox) also likely contribute to oxidative stress in pathophysiologic stages. Elevation of the renal ROS level through hyperglycemia-mediated Nox activation results in the oxidative stress which induces a damage to kidney tissues, causing to diabetic nephropathy (DN). Nox inhibitors are currently being developed as the therapeutics of DN. In this review, we summarize Nox-mediated ROS generation and development of Nox inhibitors for therapeutics of DN treatment.
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spelling pubmed-69396902020-01-03 Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors Lee, Sae Rom An, Eun Jung Kim, Jaesang Bae, Yun Soo Biomol Ther (Seoul) Review Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H(2)O(2)), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptor-mediated ROS generation for physiological signaling processes involved in cell growth, differentiation, apoptosis, and fibrosis. Detectable intracellular levels of ROS can be induced by the electron leakage from mitochondrial respiratory chain as well as by activation of cytochrome p450, glucose oxidase and xanthine oxidase, leading to oxidative stress. The up-regulation and the hyper-activation of NADPH oxidases (Nox) also likely contribute to oxidative stress in pathophysiologic stages. Elevation of the renal ROS level through hyperglycemia-mediated Nox activation results in the oxidative stress which induces a damage to kidney tissues, causing to diabetic nephropathy (DN). Nox inhibitors are currently being developed as the therapeutics of DN. In this review, we summarize Nox-mediated ROS generation and development of Nox inhibitors for therapeutics of DN treatment. The Korean Society of Applied Pharmacology 2020-01 2020-01-01 /pmc/articles/PMC6939690/ /pubmed/31875663 http://dx.doi.org/10.4062/biomolther.2019.188 Text en Copyright ©2020, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lee, Sae Rom
An, Eun Jung
Kim, Jaesang
Bae, Yun Soo
Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title_full Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title_fullStr Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title_full_unstemmed Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title_short Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
title_sort function of nadph oxidases in diabetic nephropathy and development of nox inhibitors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939690/
https://www.ncbi.nlm.nih.gov/pubmed/31875663
http://dx.doi.org/10.4062/biomolther.2019.188
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