Cardiac resynchronization therapy following Carillon(®) annuloplasty device for symptomatic heart failure and functional mitral regurgitation: a case report

BACKGROUND : Symptomatic patients with significant left ventricular systolic dysfunction (LVSD) require a tailored treatment approach. Both functional mitral regurgitation (FMR) and left bundle branch block (LBBB) can develop, contributing to clinical deterioration, and worse prognosis despite optimal medical therapy (OMT). CASE SUMMARY : We report the case of a symptomatic 60-year-old man on OMT with LVSD and significant FMR. His symptoms and FMR initially improved following transvenous mitral annuloplasty using the Carillon(®) Mitral Contour System(®) annuloplasty device. However, he subsequently developed LBBB with associated reduction in exercise capacity, for which he underwent cardiac resynchronization therapy, and ensuing symptom improvement and stabilization. DISCUSSION : Our case describes how targeted device interventions can be combined synergistically to optimize patient symptoms.