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Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
BACKGROUND: Celiac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939901/ https://www.ncbi.nlm.nih.gov/pubmed/31895924 http://dx.doi.org/10.1371/journal.pone.0226546 |
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author | Poddighe, Dimitri Turganbekova, Aida Baymukasheva, Dana Saduakas, Zhazira Zhanzakova, Zhuldyz Abdrakhmanova, Saniya |
author_facet | Poddighe, Dimitri Turganbekova, Aida Baymukasheva, Dana Saduakas, Zhazira Zhanzakova, Zhuldyz Abdrakhmanova, Saniya |
author_sort | Poddighe, Dimitri |
collection | PubMed |
description | BACKGROUND: Celiac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poorly considered in Kazakhstan, because of the assumption that CD is not prevalent in this population. OBJECTIVE: To demonstrate that the genetic predisposition to CD in Kazakhstan is not negligible and is actually comparable to Western populations. METHODS: Through the analysis of HLA-DQ genotypes of healthy bone marrow donors from Kazakhstan’s national registry, we estimated the HLA-related genetic predisposition to CD in the country. RESULTS: We demonstrated that the frequency of CD-related HLA-DQB1 alleles and, as a consequence, of predisposed individuals to CD in Kazakhstan is significant and comparable to countries with the highest disease prevalence. CONCLUSION: Considering the dietary style in Kazakhstan, including wheat as a staple food, these results provided a preliminary background of knowledge to expect a significant CD prevalence in Kazakhstan and Central Asia by implementing appropriate and cost-effective diagnostic strategies. |
format | Online Article Text |
id | pubmed-6939901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69399012020-01-10 Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia Poddighe, Dimitri Turganbekova, Aida Baymukasheva, Dana Saduakas, Zhazira Zhanzakova, Zhuldyz Abdrakhmanova, Saniya PLoS One Research Article BACKGROUND: Celiac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poorly considered in Kazakhstan, because of the assumption that CD is not prevalent in this population. OBJECTIVE: To demonstrate that the genetic predisposition to CD in Kazakhstan is not negligible and is actually comparable to Western populations. METHODS: Through the analysis of HLA-DQ genotypes of healthy bone marrow donors from Kazakhstan’s national registry, we estimated the HLA-related genetic predisposition to CD in the country. RESULTS: We demonstrated that the frequency of CD-related HLA-DQB1 alleles and, as a consequence, of predisposed individuals to CD in Kazakhstan is significant and comparable to countries with the highest disease prevalence. CONCLUSION: Considering the dietary style in Kazakhstan, including wheat as a staple food, these results provided a preliminary background of knowledge to expect a significant CD prevalence in Kazakhstan and Central Asia by implementing appropriate and cost-effective diagnostic strategies. Public Library of Science 2020-01-02 /pmc/articles/PMC6939901/ /pubmed/31895924 http://dx.doi.org/10.1371/journal.pone.0226546 Text en © 2020 Poddighe et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Poddighe, Dimitri Turganbekova, Aida Baymukasheva, Dana Saduakas, Zhazira Zhanzakova, Zhuldyz Abdrakhmanova, Saniya Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title | Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title_full | Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title_fullStr | Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title_full_unstemmed | Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title_short | Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia |
title_sort | genetic predisposition to celiac disease in kazakhstan: potential impact on the clinical practice in central asia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939901/ https://www.ncbi.nlm.nih.gov/pubmed/31895924 http://dx.doi.org/10.1371/journal.pone.0226546 |
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