Digital clubbing occurring in intrathoracic Hodgkin lymphoma: A case report

RATIONALE: Digital clubbing is rarely associated with lymphoma. This study reports a case of intrathoracic Hodgkin lymphoma with digital clubbing and reviews the current literature regarding the clinical characteristics of this condition. PATIENT CONCERN: A 21-year-old woman presented with a 3-month history of cough and 1 month of fever, with apparent digital clubbing. A computed tomography (CT) scan of the lungs revealed a large pulmonary mass. DIAGNOSIS: A CT-guided transthoracic needle biopsy was conducted. Pathology determined a diagnosis of Hodgkin lymphoma. INTERVENTIONS: The patient underwent 6 courses of chemotherapy and intensification, followed by autografting. OUTCOMES: The patient recovered and a complete hematological remission was obtained. The patient is alive with no evidence of disease 60 months after diagnosis, with the digital clubbing of the fingers and toes completely resolved. CONCLUSION: Patients with digital clubbing and intrathoracic lesions need to be examined carefully to determine tumor malignancy.