Cargando…
Can we assess the advancements of gallbladder cancer using red blood cell distribution width?
Gallbladder cancer (GBC) is a rare biliary malignancy. The relationship between red blood cell distribution width (RDW) and cancer prognosis has been confirmed by many studies, however, the relationship between RDW and gallbladder cancer is rarely reported. Therefore, we aimed to assess the correlat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940120/ https://www.ncbi.nlm.nih.gov/pubmed/31860995 http://dx.doi.org/10.1097/MD.0000000000018364 |
_version_ | 1783484299761156096 |
---|---|
author | Xie, Youjun Zhang, Lingling Zhan, Lingling |
author_facet | Xie, Youjun Zhang, Lingling Zhan, Lingling |
author_sort | Xie, Youjun |
collection | PubMed |
description | Gallbladder cancer (GBC) is a rare biliary malignancy. The relationship between red blood cell distribution width (RDW) and cancer prognosis has been confirmed by many studies, however, the relationship between RDW and gallbladder cancer is rarely reported. Therefore, we aimed to assess the correlation between RDW and the advancements of GBC in this study. A retrospective study was performed on 108 GBC patients and 119 age and gender-matched individuals who were admitted to the First Affiliated Hospital of Guangxi Medical University from January 2012 to December 2018. The GBC patients had significantly higher RDW(%) levels compared to the healthy controls group (15.7 ± 2.4 vs 13.5 ± 0.6; P = .000). In addition, GBC patients with stage III+IV had higher levels of RDW(%) than stage I+II (16.1 ± 2.5 vs 14.9 ± 2.0, P = .011). Correlation analysis showed that RDW had positive correlations with TNM stage (correlation coefficient = 0.302, P = .002). The cut-off value of RDW was observed to be 14.5% in patients with GBC (area under the curve = 0.757, 95% confidence interval = 0.677–0.838, P = .000). Univariate logistic regression and multivariate logistic regression analysis showed that RDW was an independent risk factor for GBC lymph node metastasis. Our results suggest that elevated levels of RDW are independently associated with GBC patients and may serve as potential markers for the advancements of GBC. |
format | Online Article Text |
id | pubmed-6940120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-69401202020-01-31 Can we assess the advancements of gallbladder cancer using red blood cell distribution width? Xie, Youjun Zhang, Lingling Zhan, Lingling Medicine (Baltimore) 4800 Gallbladder cancer (GBC) is a rare biliary malignancy. The relationship between red blood cell distribution width (RDW) and cancer prognosis has been confirmed by many studies, however, the relationship between RDW and gallbladder cancer is rarely reported. Therefore, we aimed to assess the correlation between RDW and the advancements of GBC in this study. A retrospective study was performed on 108 GBC patients and 119 age and gender-matched individuals who were admitted to the First Affiliated Hospital of Guangxi Medical University from January 2012 to December 2018. The GBC patients had significantly higher RDW(%) levels compared to the healthy controls group (15.7 ± 2.4 vs 13.5 ± 0.6; P = .000). In addition, GBC patients with stage III+IV had higher levels of RDW(%) than stage I+II (16.1 ± 2.5 vs 14.9 ± 2.0, P = .011). Correlation analysis showed that RDW had positive correlations with TNM stage (correlation coefficient = 0.302, P = .002). The cut-off value of RDW was observed to be 14.5% in patients with GBC (area under the curve = 0.757, 95% confidence interval = 0.677–0.838, P = .000). Univariate logistic regression and multivariate logistic regression analysis showed that RDW was an independent risk factor for GBC lymph node metastasis. Our results suggest that elevated levels of RDW are independently associated with GBC patients and may serve as potential markers for the advancements of GBC. Wolters Kluwer Health 2019-12-20 /pmc/articles/PMC6940120/ /pubmed/31860995 http://dx.doi.org/10.1097/MD.0000000000018364 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4800 Xie, Youjun Zhang, Lingling Zhan, Lingling Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title | Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title_full | Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title_fullStr | Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title_full_unstemmed | Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title_short | Can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
title_sort | can we assess the advancements of gallbladder cancer using red blood cell distribution width? |
topic | 4800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940120/ https://www.ncbi.nlm.nih.gov/pubmed/31860995 http://dx.doi.org/10.1097/MD.0000000000018364 |
work_keys_str_mv | AT xieyoujun canweassesstheadvancementsofgallbladdercancerusingredbloodcelldistributionwidth AT zhanglingling canweassesstheadvancementsofgallbladdercancerusingredbloodcelldistributionwidth AT zhanlingling canweassesstheadvancementsofgallbladdercancerusingredbloodcelldistributionwidth |