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TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity

Group 2 innate lymphoid cells (ILC2s) can initiate pathologic inflammation in allergic asthma by secreting copious amounts of type 2 cytokines, promoting lung eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma. We discovered that the TNF/TNFR2 axis is a central immune checkp...

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Detalles Bibliográficos
Autores principales:	Hurrell, Benjamin P., Galle-Treger, Lauriane, Jahani, Pedram Shafiei, Howard, Emily, Helou, Doumet Georges, Banie, Homayon, Soroosh, Pejman, Akbari, Omid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940205/ https://www.ncbi.nlm.nih.gov/pubmed/31875557 http://dx.doi.org/10.1016/j.celrep.2019.11.102

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