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Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

PURPOSE: This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro and in animal models of immune-mediated disorders. METHODS: Inhibition of human recombinant (hr)PDEs and TNF-alpha release from LPS-stimulated whole...

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Detalles Bibliográficos
Autores principales:	Świerczek, Artur, Pociecha, Krzysztof, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Baś, Sebastian, Mlynarski, Jacek, Więckowski, Krzysztof, Zadrożna, Monika, Nowak, Barbara, Wyska, Elżbieta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940354/ https://www.ncbi.nlm.nih.gov/pubmed/31899535 http://dx.doi.org/10.1007/s11095-019-2727-z

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