Cargando…

Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

PURPOSE: This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro and in animal models of immune-mediated disorders. METHODS: Inhibition of human recombinant (hr)PDEs and TNF-alpha release from LPS-stimulated whole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Świerczek, Artur, Pociecha, Krzysztof, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Baś, Sebastian, Mlynarski, Jacek, Więckowski, Krzysztof, Zadrożna, Monika, Nowak, Barbara, Wyska, Elżbieta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940354/ https://www.ncbi.nlm.nih.gov/pubmed/31899535 http://dx.doi.org/10.1007/s11095-019-2727-z

Ejemplares similares

PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis
por: Świerczek, Artur, et al.
Publicado: (2021)

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice
por: Wyska, Elżbieta, et al.
Publicado: (2015)

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases
por: Świerczek, Artur, et al.
Publicado: (2022)

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2020)

Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity
por: Zygmunt, Małgorzata, et al.
Publicado: (2022)

PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response
por: Świerczek, Artur, et al.
Publicado: (2017)

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2022)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

Anti‐inflammatory effects of dexamethasone in COVID‐19 patients: Translational population PK/PD modeling and simulation
por: Świerczek, Artur, et al.
Publicado: (2023)

Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method
por: Szafarz, Małgorzata, et al.
Publicado: (2017)

In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives
por: Marć, Małgorzata Anna, et al.
Publicado: (2017)

KSK-74: Dual Histamine H(3) and Sigma-2 Receptor Ligand with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2022)

Workshop PDE Models for Multi-Agent Phenomena
por: Cardaliaguet, Pierre, et al.
Publicado: (2018)

Learning PDE to Model Self-Organization of Matter
por: Brandao, Eduardo, et al.
Publicado: (2022)

Model‐Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
por: Sou, Tomás, et al.
Publicado: (2020)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development
por: Kayık, Gülru, et al.
Publicado: (2017)

PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development
por: Oggianu, Laura, et al.
Publicado: (2023)

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis
por: Xiao, Xia, et al.
Publicado: (2015)

Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study
por: Haliduola, Halimu N., et al.
Publicado: (2022)

Population PK and Semimechanistic PK/PD Modeling and Simulation of Relugolix Effects on Testosterone Suppression in Men with Prostate Cancer
por: Lee, Tien‐Yi, et al.
Publicado: (2022)

Regional Influenza Prediction with Sampling Twitter Data and PDE Model
por: Wang, Yufang, et al.
Publicado: (2020)

Structural identifiability analysis of age-structured PDE epidemic models
por: Renardy, Marissa, et al.
Publicado: (2022)

Hopf Bifurcations of Moore-Greitzer PDE Model with Additive Noise
por: Meng, Yiming, et al.
Publicado: (2023)

Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems
por: Sivakumar, Dakshinamurthy, et al.
Publicado: (2021)

In vivo Pharmacokinetic and Pharmacodynamic (PK/PD) Modeling and Establishment of the PK/PD Cutoff of Florfenicol Against Pasteurella multocida in Ducks
por: Xiao, Xia, et al.
Publicado: (2021)

PK/PD modeling supports the dose-escalation decision in VIKING
por: Lovern, M, et al.
Publicado: (2010)

The role of population PK–PD modelling in paediatric clinical research
por: De Cock, Roosmarijn F. W., et al.
Publicado: (2010)

PK-DB: pharmacokinetics database for individualized and stratified computational modeling
por: Grzegorzewski, Jan, et al.
Publicado: (2020)

Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models
por: Zhang, Longfei, et al.
Publicado: (2022)

Prediction of Clinical Irrelevance of PK Differences in Atorvastatin Using PK/PD Models Derived From Literature-Based Meta-Analyses
por: Vargo, R, et al.
Publicado: (2014)

1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models
por: Ghahramani, Parviz, et al.
Publicado: (2019)

MF-SuP-pK(a): Multi-fidelity modeling with subgraph pooling mechanism for pK(a) prediction
por: Wu, Jialu, et al.
Publicado: (2023)

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins
por: Mogilski, Szczepan, et al.
Publicado: (2023)

Characterization of prickle isoform-specific pk (pk1) and pk (sple1) mutations in Drosophila melanogaster
por: Lilienthal, Anthony J, et al.
Publicado: (2022)

A patient‐derived explant (PDE) model of hormone‐dependent cancer
por: Centenera, Margaret M., et al.
Publicado: (2018)

Breast Cancer Estimate Modeling via PDE Thermal Analysis Algorithms
por: Park, Young Hoon, et al.
Publicado: (2018)

Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia
por: Al-Nema, Mayasah, et al.
Publicado: (2022)

Efficient pK(a) Determination in a Nonaqueous Solvent Using Chemical Shift Imaging
por: Schenck, George, et al.
Publicado: (2022)

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation
por: Vang, Amanda G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ltgaf150d9hn1jd7snrspch7iv